A mitochondrial strategy for safeguarding the reprogrammed genome

Genomic aberrations induced by somatic cell reprogramming are a major drawback for future applications of this technology in regenerative medicine. A new study by Ji et al. published in Stem Cell Reports suggests a counteracting strategy based on balancing the mitochondrial/oxidative stress pathway...

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Detalles Bibliográficos
Autores principales: Prigione, Alessandro, Adjaye, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230514/
https://www.ncbi.nlm.nih.gov/pubmed/25408884
http://dx.doi.org/10.1186/2045-9769-3-5
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author Prigione, Alessandro
Adjaye, James
author_facet Prigione, Alessandro
Adjaye, James
author_sort Prigione, Alessandro
collection PubMed
description Genomic aberrations induced by somatic cell reprogramming are a major drawback for future applications of this technology in regenerative medicine. A new study by Ji et al. published in Stem Cell Reports suggests a counteracting strategy based on balancing the mitochondrial/oxidative stress pathway through antioxidant supplementation.
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spelling pubmed-42305142014-11-18 A mitochondrial strategy for safeguarding the reprogrammed genome Prigione, Alessandro Adjaye, James Cell Regen Commentary Genomic aberrations induced by somatic cell reprogramming are a major drawback for future applications of this technology in regenerative medicine. A new study by Ji et al. published in Stem Cell Reports suggests a counteracting strategy based on balancing the mitochondrial/oxidative stress pathway through antioxidant supplementation. BioMed Central 2014-03-29 /pmc/articles/PMC4230514/ /pubmed/25408884 http://dx.doi.org/10.1186/2045-9769-3-5 Text en © Prigione and Adjaye; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Prigione, Alessandro
Adjaye, James
A mitochondrial strategy for safeguarding the reprogrammed genome
title A mitochondrial strategy for safeguarding the reprogrammed genome
title_full A mitochondrial strategy for safeguarding the reprogrammed genome
title_fullStr A mitochondrial strategy for safeguarding the reprogrammed genome
title_full_unstemmed A mitochondrial strategy for safeguarding the reprogrammed genome
title_short A mitochondrial strategy for safeguarding the reprogrammed genome
title_sort mitochondrial strategy for safeguarding the reprogrammed genome
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230514/
https://www.ncbi.nlm.nih.gov/pubmed/25408884
http://dx.doi.org/10.1186/2045-9769-3-5
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