OCT4: A penetrant pluripotency inducer

Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and raises the intriguing question as to whether OCT4 can act non-cell-autonomously.

Detalles Bibliográficos
Autores principales: Wang, Xuecong, Jauch, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230516/
https://www.ncbi.nlm.nih.gov/pubmed/25408885
http://dx.doi.org/10.1186/2045-9769-3-6
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author Wang, Xuecong
Jauch, Ralf
author_facet Wang, Xuecong
Jauch, Ralf
author_sort Wang, Xuecong
collection PubMed
description Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and raises the intriguing question as to whether OCT4 can act non-cell-autonomously.
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spelling pubmed-42305162014-11-18 OCT4: A penetrant pluripotency inducer Wang, Xuecong Jauch, Ralf Cell Regen Commentary Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and raises the intriguing question as to whether OCT4 can act non-cell-autonomously. BioMed Central 2014-03-31 /pmc/articles/PMC4230516/ /pubmed/25408885 http://dx.doi.org/10.1186/2045-9769-3-6 Text en © Wang and Jauch; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Wang, Xuecong
Jauch, Ralf
OCT4: A penetrant pluripotency inducer
title OCT4: A penetrant pluripotency inducer
title_full OCT4: A penetrant pluripotency inducer
title_fullStr OCT4: A penetrant pluripotency inducer
title_full_unstemmed OCT4: A penetrant pluripotency inducer
title_short OCT4: A penetrant pluripotency inducer
title_sort oct4: a penetrant pluripotency inducer
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230516/
https://www.ncbi.nlm.nih.gov/pubmed/25408885
http://dx.doi.org/10.1186/2045-9769-3-6
work_keys_str_mv AT wangxuecong oct4apenetrantpluripotencyinducer
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