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Challenges and dreams: physics of weak interactions essential to life

Biological systems display stunning capacities to self-organize. Moreover, their subcellular architectures are dynamic and responsive to changing needs and conditions. Key to these properties are manifold weak “quinary” interactions that have evolved to create specific spatial networks of macromolec...

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Detalles Bibliográficos
Autores principales: Chien, Peter, Gierasch, Lila M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230606/
https://www.ncbi.nlm.nih.gov/pubmed/25368424
http://dx.doi.org/10.1091/mbc.E14-06-1035
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author Chien, Peter
Gierasch, Lila M.
author_facet Chien, Peter
Gierasch, Lila M.
author_sort Chien, Peter
collection PubMed
description Biological systems display stunning capacities to self-organize. Moreover, their subcellular architectures are dynamic and responsive to changing needs and conditions. Key to these properties are manifold weak “quinary” interactions that have evolved to create specific spatial networks of macromolecules. These specific arrangements of molecules enable signals to be propagated over distances much greater than molecular dimensions, create phase separations that define functional regions in cells, and amplify cellular responses to changes in their environments. A major challenge is to develop biochemical tools and physical models to describe the panoply of weak interactions operating in cells. We also need better approaches to measure the biases in the spatial distributions of cellular macromolecules that result from the integrated action of multiple weak interactions. Partnerships between cell biologists, biochemists, and physicists are required to deploy these methods. Together these approaches will help us realize the dream of understanding the biological “glue” that sustains life at a molecular and cellular level.
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spelling pubmed-42306062015-01-20 Challenges and dreams: physics of weak interactions essential to life Chien, Peter Gierasch, Lila M. Mol Biol Cell Perspectives Biological systems display stunning capacities to self-organize. Moreover, their subcellular architectures are dynamic and responsive to changing needs and conditions. Key to these properties are manifold weak “quinary” interactions that have evolved to create specific spatial networks of macromolecules. These specific arrangements of molecules enable signals to be propagated over distances much greater than molecular dimensions, create phase separations that define functional regions in cells, and amplify cellular responses to changes in their environments. A major challenge is to develop biochemical tools and physical models to describe the panoply of weak interactions operating in cells. We also need better approaches to measure the biases in the spatial distributions of cellular macromolecules that result from the integrated action of multiple weak interactions. Partnerships between cell biologists, biochemists, and physicists are required to deploy these methods. Together these approaches will help us realize the dream of understanding the biological “glue” that sustains life at a molecular and cellular level. The American Society for Cell Biology 2014-11-05 /pmc/articles/PMC4230606/ /pubmed/25368424 http://dx.doi.org/10.1091/mbc.E14-06-1035 Text en © 2014 Chien and Gierasch. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.
spellingShingle Perspectives
Chien, Peter
Gierasch, Lila M.
Challenges and dreams: physics of weak interactions essential to life
title Challenges and dreams: physics of weak interactions essential to life
title_full Challenges and dreams: physics of weak interactions essential to life
title_fullStr Challenges and dreams: physics of weak interactions essential to life
title_full_unstemmed Challenges and dreams: physics of weak interactions essential to life
title_short Challenges and dreams: physics of weak interactions essential to life
title_sort challenges and dreams: physics of weak interactions essential to life
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230606/
https://www.ncbi.nlm.nih.gov/pubmed/25368424
http://dx.doi.org/10.1091/mbc.E14-06-1035
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