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Mechanistic modeling confronts the complexity of molecular cell biology
Mechanistic modeling has the potential to transform how cell biologists contend with the inescapable complexity of modern biology. I am a physiologist–electrical engineer–systems biologist who has been working at the level of cell biology for the past 24 years. This perspective aims 1) to convey why...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The American Society for Cell Biology
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230610/ https://www.ncbi.nlm.nih.gov/pubmed/25368428 http://dx.doi.org/10.1091/mbc.E14-08-1333 |
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author | Phair, Robert D. |
author_facet | Phair, Robert D. |
author_sort | Phair, Robert D. |
collection | PubMed |
description | Mechanistic modeling has the potential to transform how cell biologists contend with the inescapable complexity of modern biology. I am a physiologist–electrical engineer–systems biologist who has been working at the level of cell biology for the past 24 years. This perspective aims 1) to convey why we build models, 2) to enumerate the major approaches to modeling and their philosophical differences, 3) to address some recurrent concerns raised by experimentalists, and then 4) to imagine a future in which teams of experimentalists and modelers build—and subject to exhaustive experimental tests—models covering the entire spectrum from molecular cell biology to human pathophysiology. There is, in my view, no technical obstacle to this future, but it will require some plasticity in the biological research mind-set. |
format | Online Article Text |
id | pubmed-4230610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-42306102015-01-20 Mechanistic modeling confronts the complexity of molecular cell biology Phair, Robert D. Mol Biol Cell Perspectives Mechanistic modeling has the potential to transform how cell biologists contend with the inescapable complexity of modern biology. I am a physiologist–electrical engineer–systems biologist who has been working at the level of cell biology for the past 24 years. This perspective aims 1) to convey why we build models, 2) to enumerate the major approaches to modeling and their philosophical differences, 3) to address some recurrent concerns raised by experimentalists, and then 4) to imagine a future in which teams of experimentalists and modelers build—and subject to exhaustive experimental tests—models covering the entire spectrum from molecular cell biology to human pathophysiology. There is, in my view, no technical obstacle to this future, but it will require some plasticity in the biological research mind-set. The American Society for Cell Biology 2014-11-05 /pmc/articles/PMC4230610/ /pubmed/25368428 http://dx.doi.org/10.1091/mbc.E14-08-1333 Text en © 2014 Phair. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology. |
spellingShingle | Perspectives Phair, Robert D. Mechanistic modeling confronts the complexity of molecular cell biology |
title | Mechanistic modeling confronts the complexity of molecular cell biology |
title_full | Mechanistic modeling confronts the complexity of molecular cell biology |
title_fullStr | Mechanistic modeling confronts the complexity of molecular cell biology |
title_full_unstemmed | Mechanistic modeling confronts the complexity of molecular cell biology |
title_short | Mechanistic modeling confronts the complexity of molecular cell biology |
title_sort | mechanistic modeling confronts the complexity of molecular cell biology |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230610/ https://www.ncbi.nlm.nih.gov/pubmed/25368428 http://dx.doi.org/10.1091/mbc.E14-08-1333 |
work_keys_str_mv | AT phairrobertd mechanisticmodelingconfrontsthecomplexityofmolecularcellbiology |