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Two cases of renal cell cancer during immunobiologic therapy for psoriasis

Immunobiologic therapy is indicated for severe forms of psoriasis, resistant to conventional therapy. There is growing concern about their safety profile and possible association with cancer development. This article documents two cases of renal cell cancer during treatment with biologic therapy, re...

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Detalles Bibliográficos
Autores principales: Zarur, Fabiana Palmieri, d'Almeida, Luiza Ferreira Vieira, Mafort, Monique Samy Pamplona, de Gusmão, Paula Regazzi, Avelleira, João Carlos Regazzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230681/
https://www.ncbi.nlm.nih.gov/pubmed/25387517
http://dx.doi.org/10.1590/abd1806-4841.20143257
Descripción
Sumario:Immunobiologic therapy is indicated for severe forms of psoriasis, resistant to conventional therapy. There is growing concern about their safety profile and possible association with cancer development. This article documents two cases of renal cell cancer during treatment with biologic therapy, reviewing what is described in the literature . The risk of solid tumors as a complication of using TNF-alpha inhibitors is controversial. No conclusion can be drawn from the data in the literature, however, we believe that special attention should be given to those with known risk factors for a specific neoplasm.