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Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification
PURPOSE: Inter-individual variability in clinical endpoints and occurrence of potentially severe adverse effects represent an enormous challenge in drug development at all phases of (pre-)clinical research. To ensure patient safety it is important to identify adverse events or critical subgroups wit...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230716/ https://www.ncbi.nlm.nih.gov/pubmed/25505651 http://dx.doi.org/10.1186/2193-9616-1-6 |