Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation

Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Furthermore, mutations in the gene encoding for ASYN are associated with familial and sporadic forms of PD, suggesting this protei...

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Detalles Bibliográficos
Autores principales: Lázaro, Diana F., Rodrigues, Eva F., Langohr, Ramona, Shahpasandzadeh, Hedieh, Ribeiro, Thales, Guerreiro, Patrícia, Gerhardt, Ellen, Kröhnert, Katharina, Klucken, Jochen, Pereira, Marcos D., Popova, Blagovesta, Kruse, Niels, Mollenhauer, Brit, Rizzoli, Silvio O., Braus, Gerhard H., Danzer, Karin M., Outeiro, Tiago F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230739/
https://www.ncbi.nlm.nih.gov/pubmed/25393002
http://dx.doi.org/10.1371/journal.pgen.1004741

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