I(f) current channel inhibitor (ivabradine) deserves cardioprotective effect via down-regulating the expression of matrix metalloproteinase (MMP)-2 and attenuating apoptosis in diabetic mice

BACKGROUND: Ivabradine (IVBD), a novel I(f)-channel inhibitor and specific heart rate-lowering agent, is known to have anti-oxidative activity that promotes endothelial function. However, the molecular mechanism through which IVBD acts on cardiac function has yet to be elucidated, especially in expe...

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Detalles Bibliográficos
Autores principales: Chen, Shao-Liang, Hu, Zuo-Ying, Zuo, Guang-Feng, Li, Ming-Hui, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230832/
https://www.ncbi.nlm.nih.gov/pubmed/25361902
http://dx.doi.org/10.1186/1471-2261-14-150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230832/
https://www.ncbi.nlm.nih.gov/pubmed/25361902
http://dx.doi.org/10.1186/1471-2261-14-150

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