Intramuscular Injection of AAV8 in Mice and Macaques Is Associated with Substantial Hepatic Targeting and Transgene Expression

Intramuscular (IM) administration of adeno-associated viral (AAV) vectors has entered the early stages of clinical development with some success, including the first approved gene therapy product in the West called Glybera. In preparation for broader clinical development of IM AAV vector gene therap...

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Detalles Bibliográficos
Autores principales: Greig, Jenny A., Peng, Hui, Ohlstein, Jason, Medina-Jaszek, C. Angelica, Ahonkhai, Omua, Mentzinger, Anne, Grant, Rebecca L., Roy, Soumitra, Chen, Shu-Jen, Bell, Peter, Tretiakova, Anna P., Wilson, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230988/
https://www.ncbi.nlm.nih.gov/pubmed/25393537
http://dx.doi.org/10.1371/journal.pone.0112268

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