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Inhibition of Platelet Activation and Thrombus Formation by Adenosine and Inosine: Studies on Their Relative Contribution and Molecular Modeling

BACKGROUND: The inhibitory effect of adenosine on platelet aggregation is abrogated after the addition of adenosine-deaminase. Inosine is a naturally occurring nucleoside degraded from adenosine. OBJECTIVES: The mechanisms of antiplatelet action of adenosine and inosine in vitro and in vivo, and the...

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Detalles Bibliográficos
Autores principales:	Fuentes, Eduardo, Pereira, Jaime, Mezzano, Diego, Alarcón, Marcelo, Caballero, Julio, Palomo, Iván
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231063/ https://www.ncbi.nlm.nih.gov/pubmed/25393959 http://dx.doi.org/10.1371/journal.pone.0112741

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