Clinical Application of Estimating Hepatitis B Virus Quasispecies Complexity by Massive Sequencing: Correlation between Natural Evolution and On-Treatment Evolution

AIM: To evaluate HBV quasispecies (QA) complexity in the preCore/Core regions in relation to HBeAg status, and explore QA changes under natural evolution and nucleoside analogue (NUC) treatment. METHODS: Ultra-deep pyrosequencing of HBV preCore/Core regions in 30 sequential samples (baseline [diagno...

Descripción completa

Detalles Bibliográficos
Autores principales: Homs, Maria, Caballero, Andrea, Gregori, Josep, Tabernero, David, Quer, Josep, Nieto, Leonardo, Esteban, Rafael, Buti, Maria, Rodriguez-Frias, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231103/
https://www.ncbi.nlm.nih.gov/pubmed/25393280
http://dx.doi.org/10.1371/journal.pone.0112306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231103/
https://www.ncbi.nlm.nih.gov/pubmed/25393280
http://dx.doi.org/10.1371/journal.pone.0112306

Ejemplares similares