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What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?

PURPOSE: We evaluated the utility of 10-, 12-, and 16-core prostate biopsies for detecting prostate cancer (PCa) and correlated the results with prostate-specific antigen (PSA) levels, prostate volumes, Gleason scores, and detection rates of high-grade prostatic intraepithelial neoplasia (HGPIN) and...

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Autores principales: Chambó, Renato Caretta, Tsuji, Fábio Hissachi, de Oliveira Lima, Flávio, Yamamoto, Hamilto Akihissa, de Jesus, Carlos Márcio Nóbrega
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Urological Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231149/
https://www.ncbi.nlm.nih.gov/pubmed/25405014
http://dx.doi.org/10.4111/kju.2014.55.11.725
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author Chambó, Renato Caretta
Tsuji, Fábio Hissachi
de Oliveira Lima, Flávio
Yamamoto, Hamilto Akihissa
de Jesus, Carlos Márcio Nóbrega
author_facet Chambó, Renato Caretta
Tsuji, Fábio Hissachi
de Oliveira Lima, Flávio
Yamamoto, Hamilto Akihissa
de Jesus, Carlos Márcio Nóbrega
author_sort Chambó, Renato Caretta
collection PubMed
description PURPOSE: We evaluated the utility of 10-, 12-, and 16-core prostate biopsies for detecting prostate cancer (PCa) and correlated the results with prostate-specific antigen (PSA) levels, prostate volumes, Gleason scores, and detection rates of high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP). MATERIALS AND METHODS: A prospective controlled study was conducted in 354 consecutive patients with various indications for prostate biopsy. Sixteen-core biopsy specimens were obtained from 351 patients. The first 10-core biopsy specimens were obtained bilaterally from the base, middle third, apex, medial, and latero-lateral regions. Afterward, six additional punctures were performed bilaterally in the areas more lateral to the base, middle third, and apex regions, yielding a total of 16-core biopsy specimens. The detection rate of carcinoma in the initial 10-core specimens was compared with that in the 12- and 16-core specimens. RESULTS: No significant differences in the cancer detection rate were found between the three biopsy protocols. PCa was found in 102 patients (29.06%) using the 10-core protocol, in 99 patients (28.21%) using the 12-core protocol, and in 107 patients (30.48%) using the 16-core protocol (p=0.798). The 10-, 12-, and 16-core protocols were compared with stratified PSA levels, stratified prostate volumes, Gleason scores, and detection rates of HGPIN and ASAP; no significant differences were found. CONCLUSIONS: Cancer positivity with the 10-core protocol was not significantly different from that with the 12- and 16-core protocols, which indicates that the 10-core protocol is acceptable for performing a first biopsy.
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spelling pubmed-42311492014-11-17 What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy? Chambó, Renato Caretta Tsuji, Fábio Hissachi de Oliveira Lima, Flávio Yamamoto, Hamilto Akihissa de Jesus, Carlos Márcio Nóbrega Korean J Urol Original Article PURPOSE: We evaluated the utility of 10-, 12-, and 16-core prostate biopsies for detecting prostate cancer (PCa) and correlated the results with prostate-specific antigen (PSA) levels, prostate volumes, Gleason scores, and detection rates of high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP). MATERIALS AND METHODS: A prospective controlled study was conducted in 354 consecutive patients with various indications for prostate biopsy. Sixteen-core biopsy specimens were obtained from 351 patients. The first 10-core biopsy specimens were obtained bilaterally from the base, middle third, apex, medial, and latero-lateral regions. Afterward, six additional punctures were performed bilaterally in the areas more lateral to the base, middle third, and apex regions, yielding a total of 16-core biopsy specimens. The detection rate of carcinoma in the initial 10-core specimens was compared with that in the 12- and 16-core specimens. RESULTS: No significant differences in the cancer detection rate were found between the three biopsy protocols. PCa was found in 102 patients (29.06%) using the 10-core protocol, in 99 patients (28.21%) using the 12-core protocol, and in 107 patients (30.48%) using the 16-core protocol (p=0.798). The 10-, 12-, and 16-core protocols were compared with stratified PSA levels, stratified prostate volumes, Gleason scores, and detection rates of HGPIN and ASAP; no significant differences were found. CONCLUSIONS: Cancer positivity with the 10-core protocol was not significantly different from that with the 12- and 16-core protocols, which indicates that the 10-core protocol is acceptable for performing a first biopsy. The Korean Urological Association 2014-11 2014-11-04 /pmc/articles/PMC4231149/ /pubmed/25405014 http://dx.doi.org/10.4111/kju.2014.55.11.725 Text en © The Korean Urological Association, 2014 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chambó, Renato Caretta
Tsuji, Fábio Hissachi
de Oliveira Lima, Flávio
Yamamoto, Hamilto Akihissa
de Jesus, Carlos Márcio Nóbrega
What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?
title What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?
title_full What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?
title_fullStr What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?
title_full_unstemmed What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?
title_short What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?
title_sort what is the ideal core number for ultrasound-guided prostate biopsy?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231149/
https://www.ncbi.nlm.nih.gov/pubmed/25405014
http://dx.doi.org/10.4111/kju.2014.55.11.725
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