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What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy?
PURPOSE: We evaluated the utility of 10-, 12-, and 16-core prostate biopsies for detecting prostate cancer (PCa) and correlated the results with prostate-specific antigen (PSA) levels, prostate volumes, Gleason scores, and detection rates of high-grade prostatic intraepithelial neoplasia (HGPIN) and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Urological Association
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231149/ https://www.ncbi.nlm.nih.gov/pubmed/25405014 http://dx.doi.org/10.4111/kju.2014.55.11.725 |
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author | Chambó, Renato Caretta Tsuji, Fábio Hissachi de Oliveira Lima, Flávio Yamamoto, Hamilto Akihissa de Jesus, Carlos Márcio Nóbrega |
author_facet | Chambó, Renato Caretta Tsuji, Fábio Hissachi de Oliveira Lima, Flávio Yamamoto, Hamilto Akihissa de Jesus, Carlos Márcio Nóbrega |
author_sort | Chambó, Renato Caretta |
collection | PubMed |
description | PURPOSE: We evaluated the utility of 10-, 12-, and 16-core prostate biopsies for detecting prostate cancer (PCa) and correlated the results with prostate-specific antigen (PSA) levels, prostate volumes, Gleason scores, and detection rates of high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP). MATERIALS AND METHODS: A prospective controlled study was conducted in 354 consecutive patients with various indications for prostate biopsy. Sixteen-core biopsy specimens were obtained from 351 patients. The first 10-core biopsy specimens were obtained bilaterally from the base, middle third, apex, medial, and latero-lateral regions. Afterward, six additional punctures were performed bilaterally in the areas more lateral to the base, middle third, and apex regions, yielding a total of 16-core biopsy specimens. The detection rate of carcinoma in the initial 10-core specimens was compared with that in the 12- and 16-core specimens. RESULTS: No significant differences in the cancer detection rate were found between the three biopsy protocols. PCa was found in 102 patients (29.06%) using the 10-core protocol, in 99 patients (28.21%) using the 12-core protocol, and in 107 patients (30.48%) using the 16-core protocol (p=0.798). The 10-, 12-, and 16-core protocols were compared with stratified PSA levels, stratified prostate volumes, Gleason scores, and detection rates of HGPIN and ASAP; no significant differences were found. CONCLUSIONS: Cancer positivity with the 10-core protocol was not significantly different from that with the 12- and 16-core protocols, which indicates that the 10-core protocol is acceptable for performing a first biopsy. |
format | Online Article Text |
id | pubmed-4231149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Urological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-42311492014-11-17 What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy? Chambó, Renato Caretta Tsuji, Fábio Hissachi de Oliveira Lima, Flávio Yamamoto, Hamilto Akihissa de Jesus, Carlos Márcio Nóbrega Korean J Urol Original Article PURPOSE: We evaluated the utility of 10-, 12-, and 16-core prostate biopsies for detecting prostate cancer (PCa) and correlated the results with prostate-specific antigen (PSA) levels, prostate volumes, Gleason scores, and detection rates of high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP). MATERIALS AND METHODS: A prospective controlled study was conducted in 354 consecutive patients with various indications for prostate biopsy. Sixteen-core biopsy specimens were obtained from 351 patients. The first 10-core biopsy specimens were obtained bilaterally from the base, middle third, apex, medial, and latero-lateral regions. Afterward, six additional punctures were performed bilaterally in the areas more lateral to the base, middle third, and apex regions, yielding a total of 16-core biopsy specimens. The detection rate of carcinoma in the initial 10-core specimens was compared with that in the 12- and 16-core specimens. RESULTS: No significant differences in the cancer detection rate were found between the three biopsy protocols. PCa was found in 102 patients (29.06%) using the 10-core protocol, in 99 patients (28.21%) using the 12-core protocol, and in 107 patients (30.48%) using the 16-core protocol (p=0.798). The 10-, 12-, and 16-core protocols were compared with stratified PSA levels, stratified prostate volumes, Gleason scores, and detection rates of HGPIN and ASAP; no significant differences were found. CONCLUSIONS: Cancer positivity with the 10-core protocol was not significantly different from that with the 12- and 16-core protocols, which indicates that the 10-core protocol is acceptable for performing a first biopsy. The Korean Urological Association 2014-11 2014-11-04 /pmc/articles/PMC4231149/ /pubmed/25405014 http://dx.doi.org/10.4111/kju.2014.55.11.725 Text en © The Korean Urological Association, 2014 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chambó, Renato Caretta Tsuji, Fábio Hissachi de Oliveira Lima, Flávio Yamamoto, Hamilto Akihissa de Jesus, Carlos Márcio Nóbrega What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy? |
title | What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy? |
title_full | What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy? |
title_fullStr | What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy? |
title_full_unstemmed | What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy? |
title_short | What Is the Ideal Core Number for Ultrasound-Guided Prostate Biopsy? |
title_sort | what is the ideal core number for ultrasound-guided prostate biopsy? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231149/ https://www.ncbi.nlm.nih.gov/pubmed/25405014 http://dx.doi.org/10.4111/kju.2014.55.11.725 |
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