Structure-Activity Relationships of Novel Salicylaldehyde Isonicotinoyl Hydrazone (SIH) Analogs: Iron Chelation, Anti-Oxidant and Cytotoxic Properties

Salicylaldehyde isonicotinoyl hydrazone (SIH) is a lipophilic, tridentate iron chelator with marked anti-oxidant and modest cytotoxic activity against neoplastic cells. However, it has poor stability in an aqueous environment due to the rapid hydrolysis of its hydrazone bond. In this study, we synth...

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Detalles Bibliográficos
Autores principales: Potůčková, Eliška, Hrušková, Kateřina, Bureš, Jan, Kovaříková, Petra, Špirková, Iva A., Pravdíková, Kateřina, Kolbabová, Lucie, Hergeselová, Tereza, Hašková, Pavlína, Jansová, Hana, Macháček, Miloslav, Jirkovská, Anna, Richardson, Vera, Lane, Darius J. R., Kalinowski, Danuta S., Richardson, Des R., Vávrová, Kateřina, Šimůnek, Tomáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231169/
https://www.ncbi.nlm.nih.gov/pubmed/25393531
http://dx.doi.org/10.1371/journal.pone.0112059

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