The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis

The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseas...

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Autores principales: Genua, Marco, Rutella, Sergio, Correale, Carmen, Danese, Silvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231187/
https://www.ncbi.nlm.nih.gov/pubmed/25347935
http://dx.doi.org/10.1186/s12967-014-0293-z
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author Genua, Marco
Rutella, Sergio
Correale, Carmen
Danese, Silvio
author_facet Genua, Marco
Rutella, Sergio
Correale, Carmen
Danese, Silvio
author_sort Genua, Marco
collection PubMed
description The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseases. In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis. Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions. This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches.
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spelling pubmed-42311872014-11-15 The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis Genua, Marco Rutella, Sergio Correale, Carmen Danese, Silvio J Transl Med Review The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseases. In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis. Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions. This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches. BioMed Central 2014-10-28 /pmc/articles/PMC4231187/ /pubmed/25347935 http://dx.doi.org/10.1186/s12967-014-0293-z Text en © Genua et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Genua, Marco
Rutella, Sergio
Correale, Carmen
Danese, Silvio
The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
title The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
title_full The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
title_fullStr The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
title_full_unstemmed The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
title_short The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis
title_sort triggering receptor expressed on myeloid cells (trem) in inflammatory bowel disease pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231187/
https://www.ncbi.nlm.nih.gov/pubmed/25347935
http://dx.doi.org/10.1186/s12967-014-0293-z
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