Cargando…
Accurate comparison of antibody expression levels by reproducible transgene targeting in engineered recombination-competent CHO cells
Over the years, Chinese hamster ovary (CHO) cells have emerged as the major host for expressing biotherapeutic proteins. Traditional methods to generate high-producer cell lines rely on random integration(s) of the gene of interest but have thereby left the identification of bottlenecks as a challen...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231286/ https://www.ncbi.nlm.nih.gov/pubmed/25158835 http://dx.doi.org/10.1007/s00253-014-6011-1 |