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Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study
Youth with high callous-unemotional traits (CU) are at risk for early-onset and persistent conduct problems. Research suggests that there may be different developmental pathways to CU (genetic/constitutional vs environmental), and that the absence or presence of co-occurring internalizing problems i...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231290/ https://www.ncbi.nlm.nih.gov/pubmed/25199917 http://dx.doi.org/10.1038/mp.2014.95 |
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author | Cecil, Charlotte AM Lysenko, Laura J. Jaffee, Sara R. Pingault, Jean-Baptiste Smith, Rebecca G. Relton, Caroline L. Woodward, Geoffrey McArdle, Wendy Mill, Jonathan Barker, Edward D. |
author_facet | Cecil, Charlotte AM Lysenko, Laura J. Jaffee, Sara R. Pingault, Jean-Baptiste Smith, Rebecca G. Relton, Caroline L. Woodward, Geoffrey McArdle, Wendy Mill, Jonathan Barker, Edward D. |
author_sort | Cecil, Charlotte AM |
collection | PubMed |
description | Youth with high callous-unemotional traits (CU) are at risk for early-onset and persistent conduct problems. Research suggests that there may be different developmental pathways to CU (genetic/constitutional vs environmental), and that the absence or presence of co-occurring internalizing problems is a key marker. However, it is unclear whether such a distinction is valid. Intermediate phenotypes such as DNA methylation, an epigenetic modification regulating gene expression, may help to clarify aetiological pathways. This is the first study to examine prospective inter-relationships between environmental risk (prenatal/postnatal) and DNA methylation (birth, age 7, age 9) in the prediction of CU (age 13), for youth low vs. high in internalizing problems. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously implicated in CU. Participants were 84 youth with early-onset and persistent conduct problems drawn from the Avon Longitudinal Study of Parents and Children. For youth with low internalizing problems (46%), we found that: (i) OXTR methylation at birth associated with higher CU (age 13) as well as decreased experience of victimization during childhood (birth – age 9), (ii) higher prenatal parental risks (maternal psychopathology, criminal behaviors, substance use) associated with higher OXTR methylation at birth, and (iii) OXTR methylation levels were more stable across time (birth – age 9). In contrast, for youth with high internalizing problems, CU was associated with prenatal risks of an interpersonal nature (i.e., intimate partner violence, family conflict) but not OXTR methylation. Findings support the existence of distinct developmental pathways to CU. |
format | Online Article Text |
id | pubmed-4231290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-42312902015-04-01 Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study Cecil, Charlotte AM Lysenko, Laura J. Jaffee, Sara R. Pingault, Jean-Baptiste Smith, Rebecca G. Relton, Caroline L. Woodward, Geoffrey McArdle, Wendy Mill, Jonathan Barker, Edward D. Mol Psychiatry Article Youth with high callous-unemotional traits (CU) are at risk for early-onset and persistent conduct problems. Research suggests that there may be different developmental pathways to CU (genetic/constitutional vs environmental), and that the absence or presence of co-occurring internalizing problems is a key marker. However, it is unclear whether such a distinction is valid. Intermediate phenotypes such as DNA methylation, an epigenetic modification regulating gene expression, may help to clarify aetiological pathways. This is the first study to examine prospective inter-relationships between environmental risk (prenatal/postnatal) and DNA methylation (birth, age 7, age 9) in the prediction of CU (age 13), for youth low vs. high in internalizing problems. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously implicated in CU. Participants were 84 youth with early-onset and persistent conduct problems drawn from the Avon Longitudinal Study of Parents and Children. For youth with low internalizing problems (46%), we found that: (i) OXTR methylation at birth associated with higher CU (age 13) as well as decreased experience of victimization during childhood (birth – age 9), (ii) higher prenatal parental risks (maternal psychopathology, criminal behaviors, substance use) associated with higher OXTR methylation at birth, and (iii) OXTR methylation levels were more stable across time (birth – age 9). In contrast, for youth with high internalizing problems, CU was associated with prenatal risks of an interpersonal nature (i.e., intimate partner violence, family conflict) but not OXTR methylation. Findings support the existence of distinct developmental pathways to CU. 2014-09-09 2014-10 /pmc/articles/PMC4231290/ /pubmed/25199917 http://dx.doi.org/10.1038/mp.2014.95 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Cecil, Charlotte AM Lysenko, Laura J. Jaffee, Sara R. Pingault, Jean-Baptiste Smith, Rebecca G. Relton, Caroline L. Woodward, Geoffrey McArdle, Wendy Mill, Jonathan Barker, Edward D. Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study |
title | Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study |
title_full | Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study |
title_fullStr | Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study |
title_full_unstemmed | Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study |
title_short | Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: A 13-year longitudinal study |
title_sort | environmental risk, oxytocin receptor gene (oxtr) methylation and youth callous-unemotional traits: a 13-year longitudinal study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231290/ https://www.ncbi.nlm.nih.gov/pubmed/25199917 http://dx.doi.org/10.1038/mp.2014.95 |
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