Metal-organic framework based highly selective fluorescence turn-on probe for hydrogen sulphide

Hydrogen sulphide (H(2)S) is known to play a vital role in human physiology and pathology which stimulated interest in understanding complex behaviour of H(2)S. Discerning the pathways of H(2)S production and its mode of action is still a challenge owing to its volatile and reactive nature. Herein we report azide functionalized metal-organic framework (MOF) as a selective turn-on fluorescent probe for H(2)S detection. The MOF shows highly selective and fast response towards H(2)S even in presence of other relevant biomolecules. Low cytotoxicity and H(2)S detection in live cells, demonstrate the potential of MOF towards monitoring H(2)S chemistry in biological system. To the best of our knowledge this is the first example of MOF that exhibit fast and highly selective fluorescence turn-on response towards H(2)S under physiological conditions.