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Intramural leoimyoma without endometrial cavity distortion may negatively affect the ICSI - ET outcome

BACKGROUND: To assess the impact of intramural fibroids on the intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycle outcome, when there is no compression of the endometrial cavity. METHODS: In this retrospective, matched control study, the ICSI-ET outcome of sixty-two patients (Group I)...

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Autores principales: Guven, Suleyman, Kart, Cavit, Unsal, Mesut A, Odaci, Ersan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231457/
https://www.ncbi.nlm.nih.gov/pubmed/24168009
http://dx.doi.org/10.1186/1477-7827-11-102
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author Guven, Suleyman
Kart, Cavit
Unsal, Mesut A
Odaci, Ersan
author_facet Guven, Suleyman
Kart, Cavit
Unsal, Mesut A
Odaci, Ersan
author_sort Guven, Suleyman
collection PubMed
description BACKGROUND: To assess the impact of intramural fibroids on the intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycle outcome, when there is no compression of the endometrial cavity. METHODS: In this retrospective, matched control study, the ICSI-ET outcome of sixty-two patients (Group I) with intramural fibroid (mean diameter <7 cm) and normal endometrial cavity demonstrated by office hysteroscopy was compared with matched-control group of patients (n = 301) with no fibroid (Group II). The diagnosis of fibroids was done by transvaginal ultrasonography. RESULTS: The mean age in fibroid group was 32.66 +/- 5.30 while this figure was 32.95 +/- 3.98 in control group. The clinical pregnancy rate was significantly lower in the fibroid group although fibroids not distorting the uterine cavity (25.8% vs. 39.9%, p = 0.04). In fibroid group the implantation rate was significantly lower than control group (20.97 +/- 37.93 vs.32.89 +/- 43.18%, p = 0.04). However, spontaneous abortion rate was higher in fibroid group but it did not reach the significant level (12.5% vs. 9.2%, p > 0.05). CONCLUSION: Women having intramural leiomyomas not encroaching on the uterine cavity have unfavorable ICSI/ET outcomes comparable to those of women without such leiomyomas. Therefore, myomectomy may be a good option for such patients with intramural fibroids even they do not have any endometrial distortion.
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spelling pubmed-42314572014-11-15 Intramural leoimyoma without endometrial cavity distortion may negatively affect the ICSI - ET outcome Guven, Suleyman Kart, Cavit Unsal, Mesut A Odaci, Ersan Reprod Biol Endocrinol Research BACKGROUND: To assess the impact of intramural fibroids on the intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycle outcome, when there is no compression of the endometrial cavity. METHODS: In this retrospective, matched control study, the ICSI-ET outcome of sixty-two patients (Group I) with intramural fibroid (mean diameter <7 cm) and normal endometrial cavity demonstrated by office hysteroscopy was compared with matched-control group of patients (n = 301) with no fibroid (Group II). The diagnosis of fibroids was done by transvaginal ultrasonography. RESULTS: The mean age in fibroid group was 32.66 +/- 5.30 while this figure was 32.95 +/- 3.98 in control group. The clinical pregnancy rate was significantly lower in the fibroid group although fibroids not distorting the uterine cavity (25.8% vs. 39.9%, p = 0.04). In fibroid group the implantation rate was significantly lower than control group (20.97 +/- 37.93 vs.32.89 +/- 43.18%, p = 0.04). However, spontaneous abortion rate was higher in fibroid group but it did not reach the significant level (12.5% vs. 9.2%, p > 0.05). CONCLUSION: Women having intramural leiomyomas not encroaching on the uterine cavity have unfavorable ICSI/ET outcomes comparable to those of women without such leiomyomas. Therefore, myomectomy may be a good option for such patients with intramural fibroids even they do not have any endometrial distortion. BioMed Central 2013-10-29 /pmc/articles/PMC4231457/ /pubmed/24168009 http://dx.doi.org/10.1186/1477-7827-11-102 Text en Copyright © 2013 Guven et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Guven, Suleyman
Kart, Cavit
Unsal, Mesut A
Odaci, Ersan
Intramural leoimyoma without endometrial cavity distortion may negatively affect the ICSI - ET outcome
title Intramural leoimyoma without endometrial cavity distortion may negatively affect the ICSI - ET outcome
title_full Intramural leoimyoma without endometrial cavity distortion may negatively affect the ICSI - ET outcome
title_fullStr Intramural leoimyoma without endometrial cavity distortion may negatively affect the ICSI - ET outcome
title_full_unstemmed Intramural leoimyoma without endometrial cavity distortion may negatively affect the ICSI - ET outcome
title_short Intramural leoimyoma without endometrial cavity distortion may negatively affect the ICSI - ET outcome
title_sort intramural leoimyoma without endometrial cavity distortion may negatively affect the icsi - et outcome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231457/
https://www.ncbi.nlm.nih.gov/pubmed/24168009
http://dx.doi.org/10.1186/1477-7827-11-102
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