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Fractionated Gamma Knife Radiosurgery for Benign Perioptic Tumors: Outcomes of 38 Patients in a Single Institute

BACKGROUND: This study was performed to evaluate the efficacy and safety of fractionated Gamma Knife radiosurgery (GKRS) for perioptic lesions. METHODS: Thirty-eight patients with perioptic tumors were treated at our institute from May 2004 to December 2008. All patients had a lesion in close contac...

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Autores principales: Jee, Tae Keun, Seol, Ho Jun, Im, Yong-Seok, Kong, Doo-Sik, Nam, Do-Hyun, Park, Kwan, Shin, Hyung Jin, Lee, Jung-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Brain Tumor Society; The Korean Society for Neuro-Oncology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231616/
https://www.ncbi.nlm.nih.gov/pubmed/25408926
http://dx.doi.org/10.14791/btrt.2014.2.2.56
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author Jee, Tae Keun
Seol, Ho Jun
Im, Yong-Seok
Kong, Doo-Sik
Nam, Do-Hyun
Park, Kwan
Shin, Hyung Jin
Lee, Jung-Il
author_facet Jee, Tae Keun
Seol, Ho Jun
Im, Yong-Seok
Kong, Doo-Sik
Nam, Do-Hyun
Park, Kwan
Shin, Hyung Jin
Lee, Jung-Il
author_sort Jee, Tae Keun
collection PubMed
description BACKGROUND: This study was performed to evaluate the efficacy and safety of fractionated Gamma Knife radiosurgery (GKRS) for perioptic lesions. METHODS: Thirty-eight patients with perioptic tumors were treated at our institute from May 2004 to December 2008. All patients had a lesion in close contact with the optic apparatus. Twenty-four of these patients had undergone surgical resection before fractionated GKRS. Radiation was delivered in four sessions with 12 hours intervals between sessions. The mean target volume was 3,851 mm(3) and the median cumulative marginal dose was 20 Gy. The median follow-up was 38.2 months. Visual acuity and visual fields were analyzed according to visual impairment score using the German Ophthalmological Society guidelines. RESULTS: Tumor control was achieved in 35 (94.6%) of the 37 patients with available follow-up images. Progressive tumor growth was observed in two craniopharyngioma patients (5.4%). Favorable visual outcomes in the postoperative period were achieved in 94.7% of cases (36/38). Sixteen patients showed visual function after fractionated GKRS, twenty cases were stationary, and two patients showed visual function deterioration after GKRS. CONCLUSION: GKRS is a safe and effective alternative to either surgery or fractionated radiotherapy for selected benign lesions that are adjacent to the optic apparatus.
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spelling pubmed-42316162014-11-18 Fractionated Gamma Knife Radiosurgery for Benign Perioptic Tumors: Outcomes of 38 Patients in a Single Institute Jee, Tae Keun Seol, Ho Jun Im, Yong-Seok Kong, Doo-Sik Nam, Do-Hyun Park, Kwan Shin, Hyung Jin Lee, Jung-Il Brain Tumor Res Treat Original Article BACKGROUND: This study was performed to evaluate the efficacy and safety of fractionated Gamma Knife radiosurgery (GKRS) for perioptic lesions. METHODS: Thirty-eight patients with perioptic tumors were treated at our institute from May 2004 to December 2008. All patients had a lesion in close contact with the optic apparatus. Twenty-four of these patients had undergone surgical resection before fractionated GKRS. Radiation was delivered in four sessions with 12 hours intervals between sessions. The mean target volume was 3,851 mm(3) and the median cumulative marginal dose was 20 Gy. The median follow-up was 38.2 months. Visual acuity and visual fields were analyzed according to visual impairment score using the German Ophthalmological Society guidelines. RESULTS: Tumor control was achieved in 35 (94.6%) of the 37 patients with available follow-up images. Progressive tumor growth was observed in two craniopharyngioma patients (5.4%). Favorable visual outcomes in the postoperative period were achieved in 94.7% of cases (36/38). Sixteen patients showed visual function after fractionated GKRS, twenty cases were stationary, and two patients showed visual function deterioration after GKRS. CONCLUSION: GKRS is a safe and effective alternative to either surgery or fractionated radiotherapy for selected benign lesions that are adjacent to the optic apparatus. The Korean Brain Tumor Society; The Korean Society for Neuro-Oncology 2014-10 2014-10-31 /pmc/articles/PMC4231616/ /pubmed/25408926 http://dx.doi.org/10.14791/btrt.2014.2.2.56 Text en Copyright © 2014 The Korean Brain Tumor Society and The Korean Society for Neuro-Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jee, Tae Keun
Seol, Ho Jun
Im, Yong-Seok
Kong, Doo-Sik
Nam, Do-Hyun
Park, Kwan
Shin, Hyung Jin
Lee, Jung-Il
Fractionated Gamma Knife Radiosurgery for Benign Perioptic Tumors: Outcomes of 38 Patients in a Single Institute
title Fractionated Gamma Knife Radiosurgery for Benign Perioptic Tumors: Outcomes of 38 Patients in a Single Institute
title_full Fractionated Gamma Knife Radiosurgery for Benign Perioptic Tumors: Outcomes of 38 Patients in a Single Institute
title_fullStr Fractionated Gamma Knife Radiosurgery for Benign Perioptic Tumors: Outcomes of 38 Patients in a Single Institute
title_full_unstemmed Fractionated Gamma Knife Radiosurgery for Benign Perioptic Tumors: Outcomes of 38 Patients in a Single Institute
title_short Fractionated Gamma Knife Radiosurgery for Benign Perioptic Tumors: Outcomes of 38 Patients in a Single Institute
title_sort fractionated gamma knife radiosurgery for benign perioptic tumors: outcomes of 38 patients in a single institute
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231616/
https://www.ncbi.nlm.nih.gov/pubmed/25408926
http://dx.doi.org/10.14791/btrt.2014.2.2.56
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