Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells

Decitabine (5-aza-2′-deoxycytidine) is a DNA methyltransferase inhibitor and an archetypal epigenetic drug for the therapy of myeloid leukemias. The mode of action of decitabine strictly depends on the incorporation of the drug into DNA. However, DNA incorporation and ensuing genotoxic effects of de...

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Detalles Bibliográficos
Autores principales: Öz, Simin, Raddatz, Günter, Rius, Maria, Blagitko-Dorfs, Nadja, Lübbert, Michael, Maercker, Christian, Lyko, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231731/
https://www.ncbi.nlm.nih.gov/pubmed/25159616
http://dx.doi.org/10.1093/nar/gku775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231731/
https://www.ncbi.nlm.nih.gov/pubmed/25159616
http://dx.doi.org/10.1093/nar/gku775

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