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Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity

Living in an oxygen-rich environment is dangerous for a cell. Reactive oxygen species can damage DNA, RNA, protein and lipids. The MutT protein in Escherichia coli removes 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) from the nucleotide pools precluding...

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Detalles Bibliográficos
Autores principales:	Gordon, Alasdair J.E., Satory, Dominik, Wang, Mengyu, Halliday, Jennifer A., Golding, Ido, Herman, Christophe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231768/ https://www.ncbi.nlm.nih.gov/pubmed/25294823 http://dx.doi.org/10.1093/nar/gku912

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