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The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa

Human DNA polymerase kappa (hpol κ) is the only Y-family member to preferentially insert dAMP opposite 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dG) during translesion DNA synthesis. We have studied the mechanism of action by which hpol κ activity is modulated by the Werner syndrome protein (WRN),...

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Detalles Bibliográficos
Autores principales:	Maddukuri, Leena, Ketkar, Amit, Eddy, Sarah, Zafar, Maroof K., Eoff, Robert L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231769/ https://www.ncbi.nlm.nih.gov/pubmed/25294835 http://dx.doi.org/10.1093/nar/gku913

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