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Impulsive and Compulsive Behaviors in Parkinson’s Disease
Background: Impulsive and compulsive behaviors (ICBs) are a heterogeneous group of conditions that may be caused by long-term dopaminergic replacement therapy (DRT) of Parkinson’s disease (PD). The spectrum of ICBs includes dopamine dysregulation syndrome (DDS), punding, and impulse control disorder...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231987/ https://www.ncbi.nlm.nih.gov/pubmed/25452726 http://dx.doi.org/10.3389/fnagi.2014.00318 |
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author | Zhang, Guoxin Zhang, Zhentao Liu, Ling Yang, Jiaolong Huang, Jinsha Xiong, Nian Wang, Tao |
author_facet | Zhang, Guoxin Zhang, Zhentao Liu, Ling Yang, Jiaolong Huang, Jinsha Xiong, Nian Wang, Tao |
author_sort | Zhang, Guoxin |
collection | PubMed |
description | Background: Impulsive and compulsive behaviors (ICBs) are a heterogeneous group of conditions that may be caused by long-term dopaminergic replacement therapy (DRT) of Parkinson’s disease (PD). The spectrum of ICBs includes dopamine dysregulation syndrome (DDS), punding, and impulse control disorders (ICDs). Contents: We made a detailed review regarding the epidemiology, pathology, clinical characteristics, risk factors, diagnosis as well as treatment of ICBs. Results: The prevalence of ICBs in PD patients is approximately 3–4% for DDS, 0.34–4.2% for punding, and 6–14% for ICDs, with higher prevalence in Western populations than in Asian. Those who take high dose of levodopa are more prone to have DDS, whereas, ICDs are markedly associated with dopamine agonists. Different subtypes of ICBs share many risk factors such as male gender, higher levodopa equivalent daily dose, younger age at PD onset, history of alcoholism, impulsive, or novelty-seeking personality. The Questionnaire for Impulsive–Compulsive Disorder in Parkinson’s Disease-Rating Scale seems to be a rather efficacious instrument to obtain relevant information from patients and caregivers. Treatment of ICBs is still a great challenge for clinicians. Readjustment of DRT remains the primary method. Atypical antipsychotics, antidepressants, amantadine, and psychosocial interventions are also prescribed in controlling episodes of psychosis caused by compulsive DRT, but attention should be drawn to balance ICBs symptoms and motor disorders. Moreover, deep brain stimulation of the subthalamic nucleus might be a potential method in controlling ICBs. Conclusion: The exact pathophysiological mechanisms of ICBs in PD remains poorly understood. Further researches are needed not only to study the pathogenesis, prevalence, features, and risk factors of ICBs, but to find efficacious therapy for patients with these devastating consequences. |
format | Online Article Text |
id | pubmed-4231987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42319872014-12-01 Impulsive and Compulsive Behaviors in Parkinson’s Disease Zhang, Guoxin Zhang, Zhentao Liu, Ling Yang, Jiaolong Huang, Jinsha Xiong, Nian Wang, Tao Front Aging Neurosci Neuroscience Background: Impulsive and compulsive behaviors (ICBs) are a heterogeneous group of conditions that may be caused by long-term dopaminergic replacement therapy (DRT) of Parkinson’s disease (PD). The spectrum of ICBs includes dopamine dysregulation syndrome (DDS), punding, and impulse control disorders (ICDs). Contents: We made a detailed review regarding the epidemiology, pathology, clinical characteristics, risk factors, diagnosis as well as treatment of ICBs. Results: The prevalence of ICBs in PD patients is approximately 3–4% for DDS, 0.34–4.2% for punding, and 6–14% for ICDs, with higher prevalence in Western populations than in Asian. Those who take high dose of levodopa are more prone to have DDS, whereas, ICDs are markedly associated with dopamine agonists. Different subtypes of ICBs share many risk factors such as male gender, higher levodopa equivalent daily dose, younger age at PD onset, history of alcoholism, impulsive, or novelty-seeking personality. The Questionnaire for Impulsive–Compulsive Disorder in Parkinson’s Disease-Rating Scale seems to be a rather efficacious instrument to obtain relevant information from patients and caregivers. Treatment of ICBs is still a great challenge for clinicians. Readjustment of DRT remains the primary method. Atypical antipsychotics, antidepressants, amantadine, and psychosocial interventions are also prescribed in controlling episodes of psychosis caused by compulsive DRT, but attention should be drawn to balance ICBs symptoms and motor disorders. Moreover, deep brain stimulation of the subthalamic nucleus might be a potential method in controlling ICBs. Conclusion: The exact pathophysiological mechanisms of ICBs in PD remains poorly understood. Further researches are needed not only to study the pathogenesis, prevalence, features, and risk factors of ICBs, but to find efficacious therapy for patients with these devastating consequences. Frontiers Media S.A. 2014-11-14 /pmc/articles/PMC4231987/ /pubmed/25452726 http://dx.doi.org/10.3389/fnagi.2014.00318 Text en Copyright © 2014 Zhang, Zhang, Liu, Yang, Huang, Xiong and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhang, Guoxin Zhang, Zhentao Liu, Ling Yang, Jiaolong Huang, Jinsha Xiong, Nian Wang, Tao Impulsive and Compulsive Behaviors in Parkinson’s Disease |
title | Impulsive and Compulsive Behaviors in Parkinson’s Disease |
title_full | Impulsive and Compulsive Behaviors in Parkinson’s Disease |
title_fullStr | Impulsive and Compulsive Behaviors in Parkinson’s Disease |
title_full_unstemmed | Impulsive and Compulsive Behaviors in Parkinson’s Disease |
title_short | Impulsive and Compulsive Behaviors in Parkinson’s Disease |
title_sort | impulsive and compulsive behaviors in parkinson’s disease |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231987/ https://www.ncbi.nlm.nih.gov/pubmed/25452726 http://dx.doi.org/10.3389/fnagi.2014.00318 |
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