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Vaccines to prevent leishmaniasis

Leishmaniasis is a parasitic disease that encompasses a range of clinical manifestations affecting people in tropical and subtropical regions of the world. Epidemiological and experimental data indicate that protection from disease can be achieved in most people. In addition, we know how the host im...

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Detalles Bibliográficos
Autores principales: Kumar, Rajiv, Engwerda, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232054/
https://www.ncbi.nlm.nih.gov/pubmed/25505961
http://dx.doi.org/10.1038/cti.2014.4
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author Kumar, Rajiv
Engwerda, Christian
author_facet Kumar, Rajiv
Engwerda, Christian
author_sort Kumar, Rajiv
collection PubMed
description Leishmaniasis is a parasitic disease that encompasses a range of clinical manifestations affecting people in tropical and subtropical regions of the world. Epidemiological and experimental data indicate that protection from disease can be achieved in most people. In addition, we know how the host immune system must respond to infection in order to control parasite growth. However, there is still no vaccine for use in humans. Here, we review our understanding of host immunity following Leishmania infection and also discuss recent advances in the development of vaccines to prevent leishmaniasis, highlighting a new promising approach that targets the parasite hemoglobin receptor.
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spelling pubmed-42320542014-12-11 Vaccines to prevent leishmaniasis Kumar, Rajiv Engwerda, Christian Clin Transl Immunology Review Leishmaniasis is a parasitic disease that encompasses a range of clinical manifestations affecting people in tropical and subtropical regions of the world. Epidemiological and experimental data indicate that protection from disease can be achieved in most people. In addition, we know how the host immune system must respond to infection in order to control parasite growth. However, there is still no vaccine for use in humans. Here, we review our understanding of host immunity following Leishmania infection and also discuss recent advances in the development of vaccines to prevent leishmaniasis, highlighting a new promising approach that targets the parasite hemoglobin receptor. Nature Publishing Group 2014-03-14 /pmc/articles/PMC4232054/ /pubmed/25505961 http://dx.doi.org/10.1038/cti.2014.4 Text en Copyright © 2014 Australasian Society for Immunology Inc. http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Review
Kumar, Rajiv
Engwerda, Christian
Vaccines to prevent leishmaniasis
title Vaccines to prevent leishmaniasis
title_full Vaccines to prevent leishmaniasis
title_fullStr Vaccines to prevent leishmaniasis
title_full_unstemmed Vaccines to prevent leishmaniasis
title_short Vaccines to prevent leishmaniasis
title_sort vaccines to prevent leishmaniasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232054/
https://www.ncbi.nlm.nih.gov/pubmed/25505961
http://dx.doi.org/10.1038/cti.2014.4
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