Accelerating immune reconstitution after hematopoietic stem cell transplantation

Viral infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation. Pharmacologic agents are effective against some pathogens, but they are costly and can be associated with significant toxicities. Thus, many groups have investigated adoptive T-cell...

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Detalles Bibliográficos
Autores principales: Tzannou, Ifigeneia, Leen, Ann M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232061/
https://www.ncbi.nlm.nih.gov/pubmed/25505959
http://dx.doi.org/10.1038/cti.2014.2
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author Tzannou, Ifigeneia
Leen, Ann M
author_facet Tzannou, Ifigeneia
Leen, Ann M
author_sort Tzannou, Ifigeneia
collection PubMed
description Viral infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation. Pharmacologic agents are effective against some pathogens, but they are costly and can be associated with significant toxicities. Thus, many groups have investigated adoptive T-cell transfer as a means of hastening immune reconstitution and preventing and treating viral infections. This review discusses the immunotherapeutic strategies that have been explored.
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spelling pubmed-42320612014-12-11 Accelerating immune reconstitution after hematopoietic stem cell transplantation Tzannou, Ifigeneia Leen, Ann M Clin Transl Immunology Review Viral infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation. Pharmacologic agents are effective against some pathogens, but they are costly and can be associated with significant toxicities. Thus, many groups have investigated adoptive T-cell transfer as a means of hastening immune reconstitution and preventing and treating viral infections. This review discusses the immunotherapeutic strategies that have been explored. Nature Publishing Group 2014-02-28 /pmc/articles/PMC4232061/ /pubmed/25505959 http://dx.doi.org/10.1038/cti.2014.2 Text en Copyright © 2014 Australasian Society for Immunology Inc. http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review
Tzannou, Ifigeneia
Leen, Ann M
Accelerating immune reconstitution after hematopoietic stem cell transplantation
title Accelerating immune reconstitution after hematopoietic stem cell transplantation
title_full Accelerating immune reconstitution after hematopoietic stem cell transplantation
title_fullStr Accelerating immune reconstitution after hematopoietic stem cell transplantation
title_full_unstemmed Accelerating immune reconstitution after hematopoietic stem cell transplantation
title_short Accelerating immune reconstitution after hematopoietic stem cell transplantation
title_sort accelerating immune reconstitution after hematopoietic stem cell transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232061/
https://www.ncbi.nlm.nih.gov/pubmed/25505959
http://dx.doi.org/10.1038/cti.2014.2
work_keys_str_mv AT tzannouifigeneia acceleratingimmunereconstitutionafterhematopoieticstemcelltransplantation
AT leenannm acceleratingimmunereconstitutionafterhematopoieticstemcelltransplantation

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