Cargando…

Genome-wide association study of Arabidopsis thaliana's leaf microbial community

Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses, and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a...

Descripción completa

Detalles Bibliográficos
Autores principales: Horton, Matthew W., Bodenhausen, Natacha, Beilsmith, Kathleen, Meng, Dazhe, Muegge, Brian D., Subramanian, Sathish, Vetter, M. Madlen, Vilhjálmsson, Bjarni J., Nordborg, Magnus, Gordon, Jeffrey I., Bergelson, Joy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232226/
https://www.ncbi.nlm.nih.gov/pubmed/25382143
http://dx.doi.org/10.1038/ncomms6320
_version_ 1782344532381138944
author Horton, Matthew W.
Bodenhausen, Natacha
Beilsmith, Kathleen
Meng, Dazhe
Muegge, Brian D.
Subramanian, Sathish
Vetter, M. Madlen
Vilhjálmsson, Bjarni J.
Nordborg, Magnus
Gordon, Jeffrey I.
Bergelson, Joy
author_facet Horton, Matthew W.
Bodenhausen, Natacha
Beilsmith, Kathleen
Meng, Dazhe
Muegge, Brian D.
Subramanian, Sathish
Vetter, M. Madlen
Vilhjálmsson, Bjarni J.
Nordborg, Magnus
Gordon, Jeffrey I.
Bergelson, Joy
author_sort Horton, Matthew W.
collection PubMed
description Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses, and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host's genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbes’ numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis.
format Online
Article
Text
id pubmed-4232226
institution National Center for Biotechnology Information
language English
publishDate 2014
record_format MEDLINE/PubMed
spelling pubmed-42322262015-05-10 Genome-wide association study of Arabidopsis thaliana's leaf microbial community Horton, Matthew W. Bodenhausen, Natacha Beilsmith, Kathleen Meng, Dazhe Muegge, Brian D. Subramanian, Sathish Vetter, M. Madlen Vilhjálmsson, Bjarni J. Nordborg, Magnus Gordon, Jeffrey I. Bergelson, Joy Nat Commun Article Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses, and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host's genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbes’ numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis. 2014-11-10 /pmc/articles/PMC4232226/ /pubmed/25382143 http://dx.doi.org/10.1038/ncomms6320 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Horton, Matthew W.
Bodenhausen, Natacha
Beilsmith, Kathleen
Meng, Dazhe
Muegge, Brian D.
Subramanian, Sathish
Vetter, M. Madlen
Vilhjálmsson, Bjarni J.
Nordborg, Magnus
Gordon, Jeffrey I.
Bergelson, Joy
Genome-wide association study of Arabidopsis thaliana's leaf microbial community
title Genome-wide association study of Arabidopsis thaliana's leaf microbial community
title_full Genome-wide association study of Arabidopsis thaliana's leaf microbial community
title_fullStr Genome-wide association study of Arabidopsis thaliana's leaf microbial community
title_full_unstemmed Genome-wide association study of Arabidopsis thaliana's leaf microbial community
title_short Genome-wide association study of Arabidopsis thaliana's leaf microbial community
title_sort genome-wide association study of arabidopsis thaliana's leaf microbial community
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232226/
https://www.ncbi.nlm.nih.gov/pubmed/25382143
http://dx.doi.org/10.1038/ncomms6320
work_keys_str_mv AT hortonmattheww genomewideassociationstudyofarabidopsisthalianasleafmicrobialcommunity
AT bodenhausennatacha genomewideassociationstudyofarabidopsisthalianasleafmicrobialcommunity
AT beilsmithkathleen genomewideassociationstudyofarabidopsisthalianasleafmicrobialcommunity
AT mengdazhe genomewideassociationstudyofarabidopsisthalianasleafmicrobialcommunity
AT mueggebriand genomewideassociationstudyofarabidopsisthalianasleafmicrobialcommunity
AT subramaniansathish genomewideassociationstudyofarabidopsisthalianasleafmicrobialcommunity
AT vettermmadlen genomewideassociationstudyofarabidopsisthalianasleafmicrobialcommunity
AT vilhjalmssonbjarnij genomewideassociationstudyofarabidopsisthalianasleafmicrobialcommunity
AT nordborgmagnus genomewideassociationstudyofarabidopsisthalianasleafmicrobialcommunity
AT gordonjeffreyi genomewideassociationstudyofarabidopsisthalianasleafmicrobialcommunity
AT bergelsonjoy genomewideassociationstudyofarabidopsisthalianasleafmicrobialcommunity