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Genome-wide association study of Arabidopsis thaliana's leaf microbial community
Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses, and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232226/ https://www.ncbi.nlm.nih.gov/pubmed/25382143 http://dx.doi.org/10.1038/ncomms6320 |
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author | Horton, Matthew W. Bodenhausen, Natacha Beilsmith, Kathleen Meng, Dazhe Muegge, Brian D. Subramanian, Sathish Vetter, M. Madlen Vilhjálmsson, Bjarni J. Nordborg, Magnus Gordon, Jeffrey I. Bergelson, Joy |
author_facet | Horton, Matthew W. Bodenhausen, Natacha Beilsmith, Kathleen Meng, Dazhe Muegge, Brian D. Subramanian, Sathish Vetter, M. Madlen Vilhjálmsson, Bjarni J. Nordborg, Magnus Gordon, Jeffrey I. Bergelson, Joy |
author_sort | Horton, Matthew W. |
collection | PubMed |
description | Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses, and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host's genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbes’ numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis. |
format | Online Article Text |
id | pubmed-4232226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-42322262015-05-10 Genome-wide association study of Arabidopsis thaliana's leaf microbial community Horton, Matthew W. Bodenhausen, Natacha Beilsmith, Kathleen Meng, Dazhe Muegge, Brian D. Subramanian, Sathish Vetter, M. Madlen Vilhjálmsson, Bjarni J. Nordborg, Magnus Gordon, Jeffrey I. Bergelson, Joy Nat Commun Article Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses, and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host's genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbes’ numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis. 2014-11-10 /pmc/articles/PMC4232226/ /pubmed/25382143 http://dx.doi.org/10.1038/ncomms6320 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Horton, Matthew W. Bodenhausen, Natacha Beilsmith, Kathleen Meng, Dazhe Muegge, Brian D. Subramanian, Sathish Vetter, M. Madlen Vilhjálmsson, Bjarni J. Nordborg, Magnus Gordon, Jeffrey I. Bergelson, Joy Genome-wide association study of Arabidopsis thaliana's leaf microbial community |
title | Genome-wide association study of Arabidopsis thaliana's leaf microbial community |
title_full | Genome-wide association study of Arabidopsis thaliana's leaf microbial community |
title_fullStr | Genome-wide association study of Arabidopsis thaliana's leaf microbial community |
title_full_unstemmed | Genome-wide association study of Arabidopsis thaliana's leaf microbial community |
title_short | Genome-wide association study of Arabidopsis thaliana's leaf microbial community |
title_sort | genome-wide association study of arabidopsis thaliana's leaf microbial community |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232226/ https://www.ncbi.nlm.nih.gov/pubmed/25382143 http://dx.doi.org/10.1038/ncomms6320 |
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