The crystal structure of the RhoA–AKAP-Lbc DH–PH domain complex

The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. We...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdul Azeez, Kamal R., Knapp, Stefan, Fernandes, João M. P., Klussmann, Enno, Elkins, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232260/
https://www.ncbi.nlm.nih.gov/pubmed/25186459
http://dx.doi.org/10.1042/BJ20140606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232260/
https://www.ncbi.nlm.nih.gov/pubmed/25186459
http://dx.doi.org/10.1042/BJ20140606

Ejemplares similares