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The crystal structure of the RhoA–AKAP-Lbc DH–PH domain complex

The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. We...

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Detalles Bibliográficos
Autores principales:	Abdul Azeez, Kamal R., Knapp, Stefan, Fernandes, João M. P., Klussmann, Enno, Elkins, Jonathan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232260/ https://www.ncbi.nlm.nih.gov/pubmed/25186459 http://dx.doi.org/10.1042/BJ20140606

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