Pharmacological Targeting of the Pseudokinase Her3

Her3 (ErbB3) belongs to the epidermal growth factor receptor tyrosine kinases and is well credentialed as an anti-cancer target but is thought to be “undruggable” using ATP-competitive small molecules because it lacks significant kinase activity. Here we report the first selective Her3 ligand, TX1-8...

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Detalles Bibliográficos
Autores principales: Xie, Ting, Lim, Sang Min, Westover, Kenneth D., Dodge, Michael E., Ercan, Dalia, Ficarro, Scott B., Udayakumar, Durga, Gurbani, Deepak, Tae, Hyun Seop, Riddle, Steven M., Sim, Taebo, Marto, Jarrod A., Jänne, Pasi A., Crews, Craig M., Gray, Nathanael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232461/
https://www.ncbi.nlm.nih.gov/pubmed/25326665
http://dx.doi.org/10.1038/nchembio.1658

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