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Primary Murine CD4(+) T Cells Fail to Acquire the Ability to Produce Effector Cytokines When Active Ras Is Present during Th1/Th2 Differentiation
Constitutive Ras signaling has been shown to augment IL-2 production, reverse anergy, and functionally replace many aspects of CD28 co-stimulation in CD4(+) T cells. These data raise the possibility that introduction of active Ras into primary T cells might result in improved functionality in pathol...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232516/ https://www.ncbi.nlm.nih.gov/pubmed/25397617 http://dx.doi.org/10.1371/journal.pone.0112831 |