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Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population

BACKGROUND: It has been reported that obesity and serum low-density lipoprotein cholesterol (LDL-c) are important risk factors of cardiovascular disease (CVD). It is recognized that regionalized adiposity has different cardiovascular risk, visceral versus subcutaneous, is a better predictor of CVD....

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Autores principales: Luo, Yuqi, Ma, Xiaojing, Shen, Yun, Hao, Yaping, Hu, Yaqin, Xiao, Yunfeng, Bao, Yuqian, Jia, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232522/
https://www.ncbi.nlm.nih.gov/pubmed/25398089
http://dx.doi.org/10.1371/journal.pone.0112715
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author Luo, Yuqi
Ma, Xiaojing
Shen, Yun
Hao, Yaping
Hu, Yaqin
Xiao, Yunfeng
Bao, Yuqian
Jia, Weiping
author_facet Luo, Yuqi
Ma, Xiaojing
Shen, Yun
Hao, Yaping
Hu, Yaqin
Xiao, Yunfeng
Bao, Yuqian
Jia, Weiping
author_sort Luo, Yuqi
collection PubMed
description BACKGROUND: It has been reported that obesity and serum low-density lipoprotein cholesterol (LDL-c) are important risk factors of cardiovascular disease (CVD). It is recognized that regionalized adiposity has different cardiovascular risk, visceral versus subcutaneous, is a better predictor of CVD. However, the relationship between regionalized adiposity and LDL-c is unclear. The present study was designed to investigate the relationship between visceral fat accumulation and serum LDL-c levels in a Chinese cohort. METHODS: A total of 1 538 subjects (539 men, 999 women; 20–75 years old) with normal glucose tolerance and blood pressure were recruited. All subjects underwent magnetic resonance imaging to quantify visceral fat area (VFA) and subcutaneous fat area. Serum LDL-c levels were detected by direct assay method. RESULTS: Overweight/obese subjects (body mass index (BMI) ≥25 kg/m(2)) had significantly higher serum LDL-c levels than the lean subjects (BMI <25 kg/m(2)) (P<0.01). An increasing trend in serum LDL-c levels was found to accompany the increase in VFA (P for trend <0.01). Within the same BMI category, subjects with abdominal obesity (VFA ≥80 cm(2)) had significantly higher LDL-c levels than those without abdominal obesity (VFA <80 cm(2)) (P<0.05). Multiple stepwise regression analysis showed that increased VFA was an independent risk factor for elevated LDL-c levels, not only in the entire study population (Standard β = 0.138; P<0.01), but also when the study population was subdivided into men, premenopausal and postmenopausal women (Standard β = 0.117, 0.145, 0.090 respectively for men, premenopausal women, postmenopausal women; all P<0.01). CONCLUSIONS: VFA was positively correlated with serum LDL-c levels in a nondiabetic Chinese population with normal blood pressure.
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spelling pubmed-42325222014-11-26 Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population Luo, Yuqi Ma, Xiaojing Shen, Yun Hao, Yaping Hu, Yaqin Xiao, Yunfeng Bao, Yuqian Jia, Weiping PLoS One Research Article BACKGROUND: It has been reported that obesity and serum low-density lipoprotein cholesterol (LDL-c) are important risk factors of cardiovascular disease (CVD). It is recognized that regionalized adiposity has different cardiovascular risk, visceral versus subcutaneous, is a better predictor of CVD. However, the relationship between regionalized adiposity and LDL-c is unclear. The present study was designed to investigate the relationship between visceral fat accumulation and serum LDL-c levels in a Chinese cohort. METHODS: A total of 1 538 subjects (539 men, 999 women; 20–75 years old) with normal glucose tolerance and blood pressure were recruited. All subjects underwent magnetic resonance imaging to quantify visceral fat area (VFA) and subcutaneous fat area. Serum LDL-c levels were detected by direct assay method. RESULTS: Overweight/obese subjects (body mass index (BMI) ≥25 kg/m(2)) had significantly higher serum LDL-c levels than the lean subjects (BMI <25 kg/m(2)) (P<0.01). An increasing trend in serum LDL-c levels was found to accompany the increase in VFA (P for trend <0.01). Within the same BMI category, subjects with abdominal obesity (VFA ≥80 cm(2)) had significantly higher LDL-c levels than those without abdominal obesity (VFA <80 cm(2)) (P<0.05). Multiple stepwise regression analysis showed that increased VFA was an independent risk factor for elevated LDL-c levels, not only in the entire study population (Standard β = 0.138; P<0.01), but also when the study population was subdivided into men, premenopausal and postmenopausal women (Standard β = 0.117, 0.145, 0.090 respectively for men, premenopausal women, postmenopausal women; all P<0.01). CONCLUSIONS: VFA was positively correlated with serum LDL-c levels in a nondiabetic Chinese population with normal blood pressure. Public Library of Science 2014-11-14 /pmc/articles/PMC4232522/ /pubmed/25398089 http://dx.doi.org/10.1371/journal.pone.0112715 Text en © 2014 Luo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Luo, Yuqi
Ma, Xiaojing
Shen, Yun
Hao, Yaping
Hu, Yaqin
Xiao, Yunfeng
Bao, Yuqian
Jia, Weiping
Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population
title Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population
title_full Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population
title_fullStr Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population
title_full_unstemmed Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population
title_short Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population
title_sort positive relationship between serum low-density lipoprotein cholesterol levels and visceral fat in a chinese nondiabetic population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232522/
https://www.ncbi.nlm.nih.gov/pubmed/25398089
http://dx.doi.org/10.1371/journal.pone.0112715
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