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Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population
BACKGROUND: It has been reported that obesity and serum low-density lipoprotein cholesterol (LDL-c) are important risk factors of cardiovascular disease (CVD). It is recognized that regionalized adiposity has different cardiovascular risk, visceral versus subcutaneous, is a better predictor of CVD....
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232522/ https://www.ncbi.nlm.nih.gov/pubmed/25398089 http://dx.doi.org/10.1371/journal.pone.0112715 |
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author | Luo, Yuqi Ma, Xiaojing Shen, Yun Hao, Yaping Hu, Yaqin Xiao, Yunfeng Bao, Yuqian Jia, Weiping |
author_facet | Luo, Yuqi Ma, Xiaojing Shen, Yun Hao, Yaping Hu, Yaqin Xiao, Yunfeng Bao, Yuqian Jia, Weiping |
author_sort | Luo, Yuqi |
collection | PubMed |
description | BACKGROUND: It has been reported that obesity and serum low-density lipoprotein cholesterol (LDL-c) are important risk factors of cardiovascular disease (CVD). It is recognized that regionalized adiposity has different cardiovascular risk, visceral versus subcutaneous, is a better predictor of CVD. However, the relationship between regionalized adiposity and LDL-c is unclear. The present study was designed to investigate the relationship between visceral fat accumulation and serum LDL-c levels in a Chinese cohort. METHODS: A total of 1 538 subjects (539 men, 999 women; 20–75 years old) with normal glucose tolerance and blood pressure were recruited. All subjects underwent magnetic resonance imaging to quantify visceral fat area (VFA) and subcutaneous fat area. Serum LDL-c levels were detected by direct assay method. RESULTS: Overweight/obese subjects (body mass index (BMI) ≥25 kg/m(2)) had significantly higher serum LDL-c levels than the lean subjects (BMI <25 kg/m(2)) (P<0.01). An increasing trend in serum LDL-c levels was found to accompany the increase in VFA (P for trend <0.01). Within the same BMI category, subjects with abdominal obesity (VFA ≥80 cm(2)) had significantly higher LDL-c levels than those without abdominal obesity (VFA <80 cm(2)) (P<0.05). Multiple stepwise regression analysis showed that increased VFA was an independent risk factor for elevated LDL-c levels, not only in the entire study population (Standard β = 0.138; P<0.01), but also when the study population was subdivided into men, premenopausal and postmenopausal women (Standard β = 0.117, 0.145, 0.090 respectively for men, premenopausal women, postmenopausal women; all P<0.01). CONCLUSIONS: VFA was positively correlated with serum LDL-c levels in a nondiabetic Chinese population with normal blood pressure. |
format | Online Article Text |
id | pubmed-4232522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42325222014-11-26 Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population Luo, Yuqi Ma, Xiaojing Shen, Yun Hao, Yaping Hu, Yaqin Xiao, Yunfeng Bao, Yuqian Jia, Weiping PLoS One Research Article BACKGROUND: It has been reported that obesity and serum low-density lipoprotein cholesterol (LDL-c) are important risk factors of cardiovascular disease (CVD). It is recognized that regionalized adiposity has different cardiovascular risk, visceral versus subcutaneous, is a better predictor of CVD. However, the relationship between regionalized adiposity and LDL-c is unclear. The present study was designed to investigate the relationship between visceral fat accumulation and serum LDL-c levels in a Chinese cohort. METHODS: A total of 1 538 subjects (539 men, 999 women; 20–75 years old) with normal glucose tolerance and blood pressure were recruited. All subjects underwent magnetic resonance imaging to quantify visceral fat area (VFA) and subcutaneous fat area. Serum LDL-c levels were detected by direct assay method. RESULTS: Overweight/obese subjects (body mass index (BMI) ≥25 kg/m(2)) had significantly higher serum LDL-c levels than the lean subjects (BMI <25 kg/m(2)) (P<0.01). An increasing trend in serum LDL-c levels was found to accompany the increase in VFA (P for trend <0.01). Within the same BMI category, subjects with abdominal obesity (VFA ≥80 cm(2)) had significantly higher LDL-c levels than those without abdominal obesity (VFA <80 cm(2)) (P<0.05). Multiple stepwise regression analysis showed that increased VFA was an independent risk factor for elevated LDL-c levels, not only in the entire study population (Standard β = 0.138; P<0.01), but also when the study population was subdivided into men, premenopausal and postmenopausal women (Standard β = 0.117, 0.145, 0.090 respectively for men, premenopausal women, postmenopausal women; all P<0.01). CONCLUSIONS: VFA was positively correlated with serum LDL-c levels in a nondiabetic Chinese population with normal blood pressure. Public Library of Science 2014-11-14 /pmc/articles/PMC4232522/ /pubmed/25398089 http://dx.doi.org/10.1371/journal.pone.0112715 Text en © 2014 Luo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Luo, Yuqi Ma, Xiaojing Shen, Yun Hao, Yaping Hu, Yaqin Xiao, Yunfeng Bao, Yuqian Jia, Weiping Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population |
title | Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population |
title_full | Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population |
title_fullStr | Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population |
title_full_unstemmed | Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population |
title_short | Positive Relationship between Serum Low-Density Lipoprotein Cholesterol Levels and Visceral Fat in a Chinese Nondiabetic Population |
title_sort | positive relationship between serum low-density lipoprotein cholesterol levels and visceral fat in a chinese nondiabetic population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232522/ https://www.ncbi.nlm.nih.gov/pubmed/25398089 http://dx.doi.org/10.1371/journal.pone.0112715 |
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