Drosophila Protamine-Like Mst35Ba and Mst35Bb Are Required for Proper Sperm Nuclear Morphology but Are Dispensable for Male Fertility

During spermiogenesis, histones are massively replaced with protamines. A previous report showed that Drosophila males homozygous for a genomic deletion covering several genes including the protamine-like genes Mst35Ba/b are surprisingly fertile. Here, we have precisely deleted the Mst35B locus by h...

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Detalles Bibliográficos
Autores principales: Tirmarche, Samantha, Kimura, Shuhei, Sapey-Triomphe, Laure, Sullivan, William, Landmann, Frédéric, Loppin, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2014
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232549/
https://www.ncbi.nlm.nih.gov/pubmed/25236732
http://dx.doi.org/10.1534/g3.114.012724
Descripción
Sumario:During spermiogenesis, histones are massively replaced with protamines. A previous report showed that Drosophila males homozygous for a genomic deletion covering several genes including the protamine-like genes Mst35Ba/b are surprisingly fertile. Here, we have precisely deleted the Mst35B locus by homologous recombination, and we confirm the dispensability of Mst35Ba/b for fertility.

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