Drosophila Protamine-Like Mst35Ba and Mst35Bb Are Required for Proper Sperm Nuclear Morphology but Are Dispensable for Male Fertility

During spermiogenesis, histones are massively replaced with protamines. A previous report showed that Drosophila males homozygous for a genomic deletion covering several genes including the protamine-like genes Mst35Ba/b are surprisingly fertile. Here, we have precisely deleted the Mst35B locus by h...

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Detalles Bibliográficos
Autores principales: Tirmarche, Samantha, Kimura, Shuhei, Sapey-Triomphe, Laure, Sullivan, William, Landmann, Frédéric, Loppin, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2014
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232549/
https://www.ncbi.nlm.nih.gov/pubmed/25236732
http://dx.doi.org/10.1534/g3.114.012724
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author Tirmarche, Samantha
Kimura, Shuhei
Sapey-Triomphe, Laure
Sullivan, William
Landmann, Frédéric
Loppin, Benjamin
author_facet Tirmarche, Samantha
Kimura, Shuhei
Sapey-Triomphe, Laure
Sullivan, William
Landmann, Frédéric
Loppin, Benjamin
author_sort Tirmarche, Samantha
collection PubMed
description During spermiogenesis, histones are massively replaced with protamines. A previous report showed that Drosophila males homozygous for a genomic deletion covering several genes including the protamine-like genes Mst35Ba/b are surprisingly fertile. Here, we have precisely deleted the Mst35B locus by homologous recombination, and we confirm the dispensability of Mst35Ba/b for fertility.
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spelling pubmed-42325492014-11-18 Drosophila Protamine-Like Mst35Ba and Mst35Bb Are Required for Proper Sperm Nuclear Morphology but Are Dispensable for Male Fertility Tirmarche, Samantha Kimura, Shuhei Sapey-Triomphe, Laure Sullivan, William Landmann, Frédéric Loppin, Benjamin G3 (Bethesda) Investigations During spermiogenesis, histones are massively replaced with protamines. A previous report showed that Drosophila males homozygous for a genomic deletion covering several genes including the protamine-like genes Mst35Ba/b are surprisingly fertile. Here, we have precisely deleted the Mst35B locus by homologous recombination, and we confirm the dispensability of Mst35Ba/b for fertility. Genetics Society of America 2014-09-17 /pmc/articles/PMC4232549/ /pubmed/25236732 http://dx.doi.org/10.1534/g3.114.012724 Text en Copyright © 2014 Tirmarche et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Investigations
Tirmarche, Samantha
Kimura, Shuhei
Sapey-Triomphe, Laure
Sullivan, William
Landmann, Frédéric
Loppin, Benjamin
Drosophila Protamine-Like Mst35Ba and Mst35Bb Are Required for Proper Sperm Nuclear Morphology but Are Dispensable for Male Fertility
title Drosophila Protamine-Like Mst35Ba and Mst35Bb Are Required for Proper Sperm Nuclear Morphology but Are Dispensable for Male Fertility
title_full Drosophila Protamine-Like Mst35Ba and Mst35Bb Are Required for Proper Sperm Nuclear Morphology but Are Dispensable for Male Fertility
title_fullStr Drosophila Protamine-Like Mst35Ba and Mst35Bb Are Required for Proper Sperm Nuclear Morphology but Are Dispensable for Male Fertility
title_full_unstemmed Drosophila Protamine-Like Mst35Ba and Mst35Bb Are Required for Proper Sperm Nuclear Morphology but Are Dispensable for Male Fertility
title_short Drosophila Protamine-Like Mst35Ba and Mst35Bb Are Required for Proper Sperm Nuclear Morphology but Are Dispensable for Male Fertility
title_sort drosophila protamine-like mst35ba and mst35bb are required for proper sperm nuclear morphology but are dispensable for male fertility
topic Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232549/
https://www.ncbi.nlm.nih.gov/pubmed/25236732
http://dx.doi.org/10.1534/g3.114.012724
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