Cargando…

SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling

BACKGROUND: The prevalence of obesity is increasing worldwide and significantly affects fertility and reproduction in both men and women. Our recent study has shown that excess body fat accelerates ovarian follicle development and follicle loss in rats. The aim of the present study is to explore the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Xiao-Ling, Xu, Jin-Jie, Ni, Yan-Hong, Chen, Xiao-Chun, Zhang, Hong-Xia, Zhang, Xing-Mei, Liu, Wei-Juan, Luo, Li-Li, Fu, Yu-Cai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232623/ https://www.ncbi.nlm.nih.gov/pubmed/25330910 http://dx.doi.org/10.1186/s13048-014-0097-z

Ejemplares similares

SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease
por: Chao, Chih-Chang, et al.
Publicado: (2022)

SRT2183 and SRT1720, but not Resveratrol, Inhibit Osteoclast Formation and Resorption in the Presence or Absence of Sirt1
por: Thiyagarajan, Ramkumar, et al.
Publicado: (2023)

Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice
por: Nishida, K., et al.
Publicado: (2018)

The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells
por: Gurt, Irina, et al.
Publicado: (2015)

SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485
por: Sung, Jin Young, et al.
Publicado: (2020)

The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice
por: Zhou, Dan, et al.
Publicado: (2021)

A novel dressing seeded with embryonic artery CD133(+) cells and loaded with the Sirt1 agonist SRT1720 accelerates the healing of diabetic ischemic ulcers
por: Cheng, Pan-Ke, et al.
Publicado: (2018)

SRT1720 improves survival and healthspan of obese mice
por: Minor, Robin K., et al.
Publicado: (2011)

CORRIGENDUM: SRT1720 improves survival and healthspan of obese mice
por: Minor, Robin K., et al.
Publicado: (2013)

SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model
por: Yu, Linxi, et al.
Publicado: (2017)

Cardiovascular Effects of a Novel SIRT1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers
por: Venkatasubramanian, Sowmya, et al.
Publicado: (2013)

Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus
por: Noh, Radzi M, et al.
Publicado: (2017)

Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1
por: Maiese, Kenneth
Publicado: (2020)

Dexmedetomidine postconditioning suppresses myocardial ischemia/reperfusion injury by activating the SIRT1/mTOR axis
por: Zhang, Xiong, et al.
Publicado: (2020)

Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in mice
por: Liu, Wei-Juan, et al.
Publicado: (2015)

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis
por: Krueger, James G., et al.
Publicado: (2015)

SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model
por: Wiewel, Maryse A, et al.
Publicado: (2013)

Neuroprotection of SRT2104 in Murine Ischemia/Reperfusion Injury Through the Enhancement of Sirt1-Mediated Deacetylation
por: Bai, Xue, et al.
Publicado: (2023)

Retraction: Dexmedetomidine postconditioning suppresses myocardial ischemia/reperfusion injury by activating the SIRT1/mTOR axis
Publicado: (2022)

The Sirt1 activator SRT3025 provides atheroprotection in Apoe(−/−) mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
por: Miranda, Melroy X., et al.
Publicado: (2015)

Resveratrol Ameliorates Systemic Sclerosis via Suppression of Fibrosis and Inflammation Through Activation of SIRT1/mTOR Signaling
por: Yao, Qicen, et al.
Publicado: (2020)

Expression of Concern: Dexmedetomidine postconditioning suppresses myocardial ischemia/reperfusion injury by activating the SIRT1/mTOR axis
Publicado: (2022)

Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis
por: Sands, Bruce E., et al.
Publicado: (2015)

Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy
por: Ganesan, Raja, et al.
Publicado: (2017)

Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels
por: Gombos, Zoltan, et al.
Publicado: (2021)

A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers
por: Libri, Vincenzo, et al.
Publicado: (2012)

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases
por: Manjula, Ramu, et al.
Publicado: (2021)

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity
por: Knight, John R. P., et al.
Publicado: (2013)

SIRT1 in the brain—connections with aging-associated disorders and lifespan
por: Ng, Fanny, et al.
Publicado: (2015)

Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus
por: Venkatasubramanian, Sowmya, et al.
Publicado: (2016)

Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
por: Hu, Lin, et al.
Publicado: (2021)

Inhibition of the AKT1/mTOR pathway through SIRT6 over expression downregulated the expression of programmed death-ligand 1 and prolonged overall survival in lung adenocarcinoma
por: Yuan, Zi-Fu, et al.
Publicado: (2023)

Sirt6 regulates lifespan in Drosophila melanogaster
por: Taylor, Jackson R., et al.
Publicado: (2022)

Sirt7 inhibits Sirt1-mediated activation of Suv39h1
por: Kumari, Poonam, et al.
Publicado: (2018)

COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR
por: Zhang, Chen-Yu, et al.
Publicado: (2022)

Curcumin Alleviates D-Galactose-Induced Cardiomyocyte Senescence by Promoting Autophagy via the SIRT1/AMPK/mTOR Pathway
por: Yang, Lei, et al.
Publicado: (2022)

Promotion of Ovarian Follicle Growth following mTOR Activation: Synergistic Effects of AKT Stimulators
por: Cheng, Yuan, et al.
Publicado: (2015)

SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy
por: Zhao, Wenyu, et al.
Publicado: (2018)

Protective Effect of SIRT1 Activator on the Knee With Osteoarthritis
por: Zhou, Zhenquan, et al.
Publicado: (2021)

Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy
por: Wang, Weichen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dke69kchh6aa39hm9gejgelg35