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Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats

BACKGROUND: Micronutrients in rapeseed such as polyphenols, tocopherols, phytosterols and phospholipids in rapeseed exert potential benefit to atherosclerosis. Some part of these healthy components substantially lost during the conventional refining processing. Thus some new processing technologies...

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Autores principales: Xu, Jiqu, Ma, Congcong, Han, Ling, Gao, Hui, Zhou, Qi, Yang, Mei, Chen, Chang, Deng, Qianchun, Huang, Qingde, Huang, Fenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232689/
https://www.ncbi.nlm.nih.gov/pubmed/25358951
http://dx.doi.org/10.1186/1476-511X-13-166
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author Xu, Jiqu
Ma, Congcong
Han, Ling
Gao, Hui
Zhou, Qi
Yang, Mei
Chen, Chang
Deng, Qianchun
Huang, Qingde
Huang, Fenghong
author_facet Xu, Jiqu
Ma, Congcong
Han, Ling
Gao, Hui
Zhou, Qi
Yang, Mei
Chen, Chang
Deng, Qianchun
Huang, Qingde
Huang, Fenghong
author_sort Xu, Jiqu
collection PubMed
description BACKGROUND: Micronutrients in rapeseed such as polyphenols, tocopherols, phytosterols and phospholipids in rapeseed exert potential benefit to atherosclerosis. Some part of these healthy components substantially lost during the conventional refining processing. Thus some new processing technologies have been developed to produce various endogenous micronutrient-enriched optimized rapeseed oils. The aim of this study is to assess whether optimized rapeseed oils have positive effects on the atherosclerosis risk factors in rats fed a high-fat diet. METHODS: Rats received experiment diets containing 20% fat and refined rapeseed oil or optimized rapeseed oils obtained with various processing technologies as lipid source. After 10 weeks of treatment, plasma was assayed for oxidative stress, lipid profiles and imflammation. RESULTS: Micronutrients enhancement in optimized rapeseed oils significantly reduced plasma oxidative stress, as evaluated by the significant elevation in the activities of CAT and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. Optimized rapeseed oil with the highest micronutrient contents obtained by microwave pretreatment-cold pressing reduced the levels of TG, TC and LDL-C as well as IL-6 and CRP in plasma. CONCLUSIONS: These results suggest that optimized rapeseed oils may contribute to prevent atherogenesis and make them very promising functional food in cardiovascular health promotion.
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spelling pubmed-42326892014-11-16 Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats Xu, Jiqu Ma, Congcong Han, Ling Gao, Hui Zhou, Qi Yang, Mei Chen, Chang Deng, Qianchun Huang, Qingde Huang, Fenghong Lipids Health Dis Research BACKGROUND: Micronutrients in rapeseed such as polyphenols, tocopherols, phytosterols and phospholipids in rapeseed exert potential benefit to atherosclerosis. Some part of these healthy components substantially lost during the conventional refining processing. Thus some new processing technologies have been developed to produce various endogenous micronutrient-enriched optimized rapeseed oils. The aim of this study is to assess whether optimized rapeseed oils have positive effects on the atherosclerosis risk factors in rats fed a high-fat diet. METHODS: Rats received experiment diets containing 20% fat and refined rapeseed oil or optimized rapeseed oils obtained with various processing technologies as lipid source. After 10 weeks of treatment, plasma was assayed for oxidative stress, lipid profiles and imflammation. RESULTS: Micronutrients enhancement in optimized rapeseed oils significantly reduced plasma oxidative stress, as evaluated by the significant elevation in the activities of CAT and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. Optimized rapeseed oil with the highest micronutrient contents obtained by microwave pretreatment-cold pressing reduced the levels of TG, TC and LDL-C as well as IL-6 and CRP in plasma. CONCLUSIONS: These results suggest that optimized rapeseed oils may contribute to prevent atherogenesis and make them very promising functional food in cardiovascular health promotion. BioMed Central 2014-10-30 /pmc/articles/PMC4232689/ /pubmed/25358951 http://dx.doi.org/10.1186/1476-511X-13-166 Text en © Xu et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Xu, Jiqu
Ma, Congcong
Han, Ling
Gao, Hui
Zhou, Qi
Yang, Mei
Chen, Chang
Deng, Qianchun
Huang, Qingde
Huang, Fenghong
Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats
title Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats
title_full Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats
title_fullStr Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats
title_full_unstemmed Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats
title_short Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats
title_sort optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232689/
https://www.ncbi.nlm.nih.gov/pubmed/25358951
http://dx.doi.org/10.1186/1476-511X-13-166
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