Identifying diagnostic DNA methylation profiles for facioscapulohumeral muscular dystrophy in blood and saliva using bisulfite sequencing

BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD) is linked to chromatin relaxation due to epigenetic changes at the 4q35 D4Z4 macrosatellite array. Molecular diagnostic criteria for FSHD are complex and involve analysis of high molecular weight (HMW) genomic DNA isolated from lymphocytes, f...

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Detalles Bibliográficos
Autores principales: Jones, Takako I, Yan, Chi, Sapp, Peter C, McKenna-Yasek, Diane, Kang, Peter B, Quinn, Colin, Salameh, Johnny S, King, Oliver D, Jones, Peter L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232706/
https://www.ncbi.nlm.nih.gov/pubmed/25400706
http://dx.doi.org/10.1186/1868-7083-6-23

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