The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels

ATOH8 has previously been shown to be an iron-regulated transcription factor, however its role in iron metabolism is not known. ATOH8 expression in HEK293 cells resulted in increased endogenous HAMP mRNA levels as well as HAMP promoter activity. Mutation of the E-box or SMAD response elements within...

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Detalles Bibliográficos
Autores principales: Patel, Neeta, Varghese, Joe, Masaratana, Patarabutr, Latunde-Dada, Gladys O, Jacob, Molly, Simpson, Robert J, McKie, Andrew T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Red Cells and Iron
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232863/
https://www.ncbi.nlm.nih.gov/pubmed/24236640
http://dx.doi.org/10.1111/bjh.12649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232863/
https://www.ncbi.nlm.nih.gov/pubmed/24236640
http://dx.doi.org/10.1111/bjh.12649

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