Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system

The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system (CNS) malfunction has triggered intensive investigation of the biological roles played by DISC1...

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Autores principales: Randall, Andrew D, Kurihara, Mai, Brandon, Nicholas J, Brown, Jon T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Special Issue: Synaptic Basis of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232872/
https://www.ncbi.nlm.nih.gov/pubmed/24712987
http://dx.doi.org/10.1111/ejn.12500
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author Randall, Andrew D
Kurihara, Mai
Brandon, Nicholas J
Brown, Jon T
author_facet Randall, Andrew D
Kurihara, Mai
Brandon, Nicholas J
Brown, Jon T
author_sort Randall, Andrew D
collection PubMed
description The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system (CNS) malfunction has triggered intensive investigation of the biological roles played by DISC1, with the hope that this may shed new light on the pathobiology of psychiatric disease. Such work has ranged from investigations of animal behavior to detailed molecular-level analysis of the assemblies that DISC1 forms with other proteins. Here, we discuss the evidence for a role of DISC1 in synaptic function in the mammalian CNS.
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spelling pubmed-42328722014-12-19 Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system Randall, Andrew D Kurihara, Mai Brandon, Nicholas J Brown, Jon T Eur J Neurosci Special Issue: Synaptic Basis of Disease The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system (CNS) malfunction has triggered intensive investigation of the biological roles played by DISC1, with the hope that this may shed new light on the pathobiology of psychiatric disease. Such work has ranged from investigations of animal behavior to detailed molecular-level analysis of the assemblies that DISC1 forms with other proteins. Here, we discuss the evidence for a role of DISC1 in synaptic function in the mammalian CNS. BlackWell Publishing Ltd 2014-04 2014-04-08 /pmc/articles/PMC4232872/ /pubmed/24712987 http://dx.doi.org/10.1111/ejn.12500 Text en Copyright © 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Issue: Synaptic Basis of Disease
Randall, Andrew D
Kurihara, Mai
Brandon, Nicholas J
Brown, Jon T
Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
title Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
title_full Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
title_fullStr Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
title_full_unstemmed Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
title_short Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
title_sort disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
topic Special Issue: Synaptic Basis of Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232872/
https://www.ncbi.nlm.nih.gov/pubmed/24712987
http://dx.doi.org/10.1111/ejn.12500
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AT brandonnicholasj disruptedinschizophrenia1andsynapticfunctioninthemammaliancentralnervoussystem
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