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A model and nomogram to predict tumor site origin for squamous cell cancer confined to cervical lymph nodes

BACKGROUND: The current study was conducted to develop a multifactorial statistical model to predict the specific head and neck (H&N) tumor site origin in cases of squamous cell carcinoma confined to the cervical lymph nodes (“unknown primaries”). METHODS: The Surveillance, Epidemiology, and End...

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Autores principales: Ali, Arif N, Switchenko, Jeffrey M, Kim, Sungjin, Kowalski, Jeanne, El-Deiry, Mark W, Beitler, Jonathan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232899/
https://www.ncbi.nlm.nih.gov/pubmed/25060659
http://dx.doi.org/10.1002/cncr.28901
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author Ali, Arif N
Switchenko, Jeffrey M
Kim, Sungjin
Kowalski, Jeanne
El-Deiry, Mark W
Beitler, Jonathan J
author_facet Ali, Arif N
Switchenko, Jeffrey M
Kim, Sungjin
Kowalski, Jeanne
El-Deiry, Mark W
Beitler, Jonathan J
author_sort Ali, Arif N
collection PubMed
description BACKGROUND: The current study was conducted to develop a multifactorial statistical model to predict the specific head and neck (H&N) tumor site origin in cases of squamous cell carcinoma confined to the cervical lymph nodes (“unknown primaries”). METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for patients with an H&N tumor site who were diagnosed between 2004 and 2011. The SEER patients were identified according to their H&N primary tumor site and clinically positive cervical lymph node levels at the time of presentation. The SEER patient data set was randomly divided into 2 data sets for the purposes of internal split-sample validation. The effects of cervical lymph node levels, age, race, and sex on H&N primary tumor site were examined using univariate and multivariate analyses. Multivariate logistic regression models and an associated set of nomograms were developed based on relevant factors to provide probabilities of tumor site origin. RESULTS: Analysis of the SEER database identified 20,011 patients with H&N disease with both site-level and lymph node-level data. Sex, race, age, and lymph node levels were associated with primary H&N tumor site (nasopharynx, hypopharynx, oropharynx, and larynx) in the multivariate models. Internal validation techniques affirmed the accuracy of these models on separate data. CONCLUSIONS: The incorporation of epidemiologic and lymph node data into a predictive model has the potential to provide valuable guidance to clinicians in the treatment of patients with squamous cell carcinoma confined to the cervical lymph nodes.
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spelling pubmed-42328992014-12-15 A model and nomogram to predict tumor site origin for squamous cell cancer confined to cervical lymph nodes Ali, Arif N Switchenko, Jeffrey M Kim, Sungjin Kowalski, Jeanne El-Deiry, Mark W Beitler, Jonathan J Cancer Original Articles BACKGROUND: The current study was conducted to develop a multifactorial statistical model to predict the specific head and neck (H&N) tumor site origin in cases of squamous cell carcinoma confined to the cervical lymph nodes (“unknown primaries”). METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for patients with an H&N tumor site who were diagnosed between 2004 and 2011. The SEER patients were identified according to their H&N primary tumor site and clinically positive cervical lymph node levels at the time of presentation. The SEER patient data set was randomly divided into 2 data sets for the purposes of internal split-sample validation. The effects of cervical lymph node levels, age, race, and sex on H&N primary tumor site were examined using univariate and multivariate analyses. Multivariate logistic regression models and an associated set of nomograms were developed based on relevant factors to provide probabilities of tumor site origin. RESULTS: Analysis of the SEER database identified 20,011 patients with H&N disease with both site-level and lymph node-level data. Sex, race, age, and lymph node levels were associated with primary H&N tumor site (nasopharynx, hypopharynx, oropharynx, and larynx) in the multivariate models. Internal validation techniques affirmed the accuracy of these models on separate data. CONCLUSIONS: The incorporation of epidemiologic and lymph node data into a predictive model has the potential to provide valuable guidance to clinicians in the treatment of patients with squamous cell carcinoma confined to the cervical lymph nodes. BlackWell Publishing Ltd 2014-11-15 2014-07-24 /pmc/articles/PMC4232899/ /pubmed/25060659 http://dx.doi.org/10.1002/cncr.28901 Text en © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Ali, Arif N
Switchenko, Jeffrey M
Kim, Sungjin
Kowalski, Jeanne
El-Deiry, Mark W
Beitler, Jonathan J
A model and nomogram to predict tumor site origin for squamous cell cancer confined to cervical lymph nodes
title A model and nomogram to predict tumor site origin for squamous cell cancer confined to cervical lymph nodes
title_full A model and nomogram to predict tumor site origin for squamous cell cancer confined to cervical lymph nodes
title_fullStr A model and nomogram to predict tumor site origin for squamous cell cancer confined to cervical lymph nodes
title_full_unstemmed A model and nomogram to predict tumor site origin for squamous cell cancer confined to cervical lymph nodes
title_short A model and nomogram to predict tumor site origin for squamous cell cancer confined to cervical lymph nodes
title_sort model and nomogram to predict tumor site origin for squamous cell cancer confined to cervical lymph nodes
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232899/
https://www.ncbi.nlm.nih.gov/pubmed/25060659
http://dx.doi.org/10.1002/cncr.28901
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