Nonsense-mediated RNA decay: at the ‘cutting edge’ of regulated snoRNA production

Production of multiple functional RNAs from a single primary transcript is an extremely efficient use of genetic information, although it complicates the ability of the cell to independently regulate the production of each RNA. For the case of small nucleolar RNAs (snoRNAs) encoded within introns of...

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Detalles Bibliográficos
Autores principales: Wilusz, Jeremy E., Wilusz, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233238/
https://www.ncbi.nlm.nih.gov/pubmed/25403177
http://dx.doi.org/10.1101/gad.254193.114
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author Wilusz, Jeremy E.
Wilusz, Jeffrey
author_facet Wilusz, Jeremy E.
Wilusz, Jeffrey
author_sort Wilusz, Jeremy E.
collection PubMed
description Production of multiple functional RNAs from a single primary transcript is an extremely efficient use of genetic information, although it complicates the ability of the cell to independently regulate the production of each RNA. For the case of small nucleolar RNAs (snoRNAs) encoded within introns of mRNA genes, Lykke-Andersen and colleagues (pp. 2498–2517) demonstrated that alternative splicing and the SMG6 endonuclease of the nonsense-mediated RNA decay pathway are key regulators that control which RNAs accumulate.
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spelling pubmed-42332382015-05-15 Nonsense-mediated RNA decay: at the ‘cutting edge’ of regulated snoRNA production Wilusz, Jeremy E. Wilusz, Jeffrey Genes Dev Perspective Production of multiple functional RNAs from a single primary transcript is an extremely efficient use of genetic information, although it complicates the ability of the cell to independently regulate the production of each RNA. For the case of small nucleolar RNAs (snoRNAs) encoded within introns of mRNA genes, Lykke-Andersen and colleagues (pp. 2498–2517) demonstrated that alternative splicing and the SMG6 endonuclease of the nonsense-mediated RNA decay pathway are key regulators that control which RNAs accumulate. Cold Spring Harbor Laboratory Press 2014-11-15 /pmc/articles/PMC4233238/ /pubmed/25403177 http://dx.doi.org/10.1101/gad.254193.114 Text en © 2014 Wilusz and Wilusz; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Perspective
Wilusz, Jeremy E.
Wilusz, Jeffrey
Nonsense-mediated RNA decay: at the ‘cutting edge’ of regulated snoRNA production
title Nonsense-mediated RNA decay: at the ‘cutting edge’ of regulated snoRNA production
title_full Nonsense-mediated RNA decay: at the ‘cutting edge’ of regulated snoRNA production
title_fullStr Nonsense-mediated RNA decay: at the ‘cutting edge’ of regulated snoRNA production
title_full_unstemmed Nonsense-mediated RNA decay: at the ‘cutting edge’ of regulated snoRNA production
title_short Nonsense-mediated RNA decay: at the ‘cutting edge’ of regulated snoRNA production
title_sort nonsense-mediated rna decay: at the ‘cutting edge’ of regulated snorna production
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233238/
https://www.ncbi.nlm.nih.gov/pubmed/25403177
http://dx.doi.org/10.1101/gad.254193.114
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