TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

The semiconservative replication of telomeres is facilitated by the shelterin component TRF1. Without TRF1, replication forks stall in the telomeric repeats, leading to ATR kinase signaling upon S-phase progression, fragile metaphase telomeres that resemble the common fragile sites (CFSs), and the a...

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Detalles Bibliográficos
Autores principales: Zimmermann, Michal, Kibe, Tatsuya, Kabir, Shaheen, de Lange, Titia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233241/
https://www.ncbi.nlm.nih.gov/pubmed/25344324
http://dx.doi.org/10.1101/gad.251611.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233241/
https://www.ncbi.nlm.nih.gov/pubmed/25344324
http://dx.doi.org/10.1101/gad.251611.114

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