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Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle
In Takotsubo cardiomyopathy, the left ventricle shows apical ballooning combined with basal hypercontractility. Both clinical observations in humans and recent experimental work on isolated rat ventricular myocytes suggest the dominant mechanisms of this syndrome are related to acute catecholamine o...
Autores principales: | Land, Sander, Niederer, Steven A., Louch, William E., Røe, Åsmund T., Aronsen, Jan Magnus, Stuckey, Daniel J., Sikkel, Markus B., Tranter, Matthew H., Lyon, Alexander R., Harding, Sian E., Smith, Nicolas P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Physiological Society
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233305/ https://www.ncbi.nlm.nih.gov/pubmed/25239804 http://dx.doi.org/10.1152/ajpheart.00443.2014 |
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