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The roles of Jumonji-type oxygenases in human disease

The iron- and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on various types of substrates, including metabolic intermediates, amino acid residues in different proteins and various types of nucle...

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Autores principales: Johansson, Catrine, Tumber, Anthony, Che, KaHing, Cain, Peter, Nowak, Radoslaw, Gileadi, Carina, Oppermann, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233403/
https://www.ncbi.nlm.nih.gov/pubmed/24579949
http://dx.doi.org/10.2217/epi.13.79
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author Johansson, Catrine
Tumber, Anthony
Che, KaHing
Cain, Peter
Nowak, Radoslaw
Gileadi, Carina
Oppermann, Udo
author_facet Johansson, Catrine
Tumber, Anthony
Che, KaHing
Cain, Peter
Nowak, Radoslaw
Gileadi, Carina
Oppermann, Udo
author_sort Johansson, Catrine
collection PubMed
description The iron- and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on various types of substrates, including metabolic intermediates, amino acid residues in different proteins and various types of nucleic acids. The discovery of jumonji (Jmj), the founding member of a class of Jmj-type chromatin-modifying enzymes and transcriptional regulators, has culminated in the discovery of several branches of histone lysine demethylases, with essential functions in regulating the epigenetic landscape of the chromatin environment. This work has now been considerably expanded into other aspects of epigenetic biology and includes the discovery of enzymatic steps required for methyl-cytosine demethylation, as well as modification of RNA and ribosomal proteins. This overview aims to summarize the current knowledge on the human Jmj-type enzymes and their involvement in human pathological processes, including development, cancer, inflammation and metabolic diseases.
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spelling pubmed-42334032014-11-17 The roles of Jumonji-type oxygenases in human disease Johansson, Catrine Tumber, Anthony Che, KaHing Cain, Peter Nowak, Radoslaw Gileadi, Carina Oppermann, Udo Epigenomics Article The iron- and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on various types of substrates, including metabolic intermediates, amino acid residues in different proteins and various types of nucleic acids. The discovery of jumonji (Jmj), the founding member of a class of Jmj-type chromatin-modifying enzymes and transcriptional regulators, has culminated in the discovery of several branches of histone lysine demethylases, with essential functions in regulating the epigenetic landscape of the chromatin environment. This work has now been considerably expanded into other aspects of epigenetic biology and includes the discovery of enzymatic steps required for methyl-cytosine demethylation, as well as modification of RNA and ribosomal proteins. This overview aims to summarize the current knowledge on the human Jmj-type enzymes and their involvement in human pathological processes, including development, cancer, inflammation and metabolic diseases. 2014-02 /pmc/articles/PMC4233403/ /pubmed/24579949 http://dx.doi.org/10.2217/epi.13.79 Text en © 2014 Udo Oppermann This article is distributed under the terms of the Creative Commons Attribution License 3.0 which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. To view a copy of the license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Article
Johansson, Catrine
Tumber, Anthony
Che, KaHing
Cain, Peter
Nowak, Radoslaw
Gileadi, Carina
Oppermann, Udo
The roles of Jumonji-type oxygenases in human disease
title The roles of Jumonji-type oxygenases in human disease
title_full The roles of Jumonji-type oxygenases in human disease
title_fullStr The roles of Jumonji-type oxygenases in human disease
title_full_unstemmed The roles of Jumonji-type oxygenases in human disease
title_short The roles of Jumonji-type oxygenases in human disease
title_sort roles of jumonji-type oxygenases in human disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233403/
https://www.ncbi.nlm.nih.gov/pubmed/24579949
http://dx.doi.org/10.2217/epi.13.79
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