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The roles of Jumonji-type oxygenases in human disease
The iron- and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on various types of substrates, including metabolic intermediates, amino acid residues in different proteins and various types of nucle...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233403/ https://www.ncbi.nlm.nih.gov/pubmed/24579949 http://dx.doi.org/10.2217/epi.13.79 |
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author | Johansson, Catrine Tumber, Anthony Che, KaHing Cain, Peter Nowak, Radoslaw Gileadi, Carina Oppermann, Udo |
author_facet | Johansson, Catrine Tumber, Anthony Che, KaHing Cain, Peter Nowak, Radoslaw Gileadi, Carina Oppermann, Udo |
author_sort | Johansson, Catrine |
collection | PubMed |
description | The iron- and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on various types of substrates, including metabolic intermediates, amino acid residues in different proteins and various types of nucleic acids. The discovery of jumonji (Jmj), the founding member of a class of Jmj-type chromatin-modifying enzymes and transcriptional regulators, has culminated in the discovery of several branches of histone lysine demethylases, with essential functions in regulating the epigenetic landscape of the chromatin environment. This work has now been considerably expanded into other aspects of epigenetic biology and includes the discovery of enzymatic steps required for methyl-cytosine demethylation, as well as modification of RNA and ribosomal proteins. This overview aims to summarize the current knowledge on the human Jmj-type enzymes and their involvement in human pathological processes, including development, cancer, inflammation and metabolic diseases. |
format | Online Article Text |
id | pubmed-4233403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-42334032014-11-17 The roles of Jumonji-type oxygenases in human disease Johansson, Catrine Tumber, Anthony Che, KaHing Cain, Peter Nowak, Radoslaw Gileadi, Carina Oppermann, Udo Epigenomics Article The iron- and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on various types of substrates, including metabolic intermediates, amino acid residues in different proteins and various types of nucleic acids. The discovery of jumonji (Jmj), the founding member of a class of Jmj-type chromatin-modifying enzymes and transcriptional regulators, has culminated in the discovery of several branches of histone lysine demethylases, with essential functions in regulating the epigenetic landscape of the chromatin environment. This work has now been considerably expanded into other aspects of epigenetic biology and includes the discovery of enzymatic steps required for methyl-cytosine demethylation, as well as modification of RNA and ribosomal proteins. This overview aims to summarize the current knowledge on the human Jmj-type enzymes and their involvement in human pathological processes, including development, cancer, inflammation and metabolic diseases. 2014-02 /pmc/articles/PMC4233403/ /pubmed/24579949 http://dx.doi.org/10.2217/epi.13.79 Text en © 2014 Udo Oppermann This article is distributed under the terms of the Creative Commons Attribution License 3.0 which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. To view a copy of the license, visit http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Article Johansson, Catrine Tumber, Anthony Che, KaHing Cain, Peter Nowak, Radoslaw Gileadi, Carina Oppermann, Udo The roles of Jumonji-type oxygenases in human disease |
title | The roles of Jumonji-type oxygenases in human disease |
title_full | The roles of Jumonji-type oxygenases in human disease |
title_fullStr | The roles of Jumonji-type oxygenases in human disease |
title_full_unstemmed | The roles of Jumonji-type oxygenases in human disease |
title_short | The roles of Jumonji-type oxygenases in human disease |
title_sort | roles of jumonji-type oxygenases in human disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233403/ https://www.ncbi.nlm.nih.gov/pubmed/24579949 http://dx.doi.org/10.2217/epi.13.79 |
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