Enzymatic aspects in ENT cancer-Matrix metalloproteinases

Abstract The study of ENT cancer allows the implementation of molecular biology methods in diagnosis, predicting the evolution of the disease and suggesting a certain treatment. MMPs are proteolytic enzymes, zinc dependent endopeptidases, secreted by tissues and proinflammatory cells that play a rol...

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Detalles Bibliográficos
Autores principales: Zamfir Chiru, AA, Popescu, CR, Gheorghe, DC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2014
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233443/
https://www.ncbi.nlm.nih.gov/pubmed/25408759
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author Zamfir Chiru, AA
Popescu, CR
Gheorghe, DC
author_facet Zamfir Chiru, AA
Popescu, CR
Gheorghe, DC
author_sort Zamfir Chiru, AA
collection PubMed
description Abstract The study of ENT cancer allows the implementation of molecular biology methods in diagnosis, predicting the evolution of the disease and suggesting a certain treatment. MMPs are proteolytic enzymes, zinc dependent endopeptidases, secreted by tissues and proinflammatory cells that play a role in the clearance of cell surface receptors. They are expressed as zymogens (inactive forms). Proteolytic enzymes cleave zymogens generating active forms. They are involved in cell proliferation, adhesion, differentiation, migration, angiogenesis, apoptosis and host defense.
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spelling pubmed-42334432014-11-18 Enzymatic aspects in ENT cancer-Matrix metalloproteinases Zamfir Chiru, AA Popescu, CR Gheorghe, DC J Med Life General Article Abstract The study of ENT cancer allows the implementation of molecular biology methods in diagnosis, predicting the evolution of the disease and suggesting a certain treatment. MMPs are proteolytic enzymes, zinc dependent endopeptidases, secreted by tissues and proinflammatory cells that play a role in the clearance of cell surface receptors. They are expressed as zymogens (inactive forms). Proteolytic enzymes cleave zymogens generating active forms. They are involved in cell proliferation, adhesion, differentiation, migration, angiogenesis, apoptosis and host defense. Carol Davila University Press 2014-09-15 2014-09-25 /pmc/articles/PMC4233443/ /pubmed/25408759 Text en ©Carol Davila University Press http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle General Article
Zamfir Chiru, AA
Popescu, CR
Gheorghe, DC
Enzymatic aspects in ENT cancer-Matrix metalloproteinases
title Enzymatic aspects in ENT cancer-Matrix metalloproteinases
title_full Enzymatic aspects in ENT cancer-Matrix metalloproteinases
title_fullStr Enzymatic aspects in ENT cancer-Matrix metalloproteinases
title_full_unstemmed Enzymatic aspects in ENT cancer-Matrix metalloproteinases
title_short Enzymatic aspects in ENT cancer-Matrix metalloproteinases
title_sort enzymatic aspects in ent cancer-matrix metalloproteinases
topic General Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233443/
https://www.ncbi.nlm.nih.gov/pubmed/25408759
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AT popescucr enzymaticaspectsinentcancermatrixmetalloproteinases
AT gheorghedc enzymaticaspectsinentcancermatrixmetalloproteinases

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