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Extracellular matrix production in vitro in cartilage tissue engineering

Cartilage tissue engineering is arising as a technique for the repair of cartilage lesions in clinical applications. However, fibrocartilage formation weakened the mechanical functions of the articular, which compromises the clinical outcomes. Due to the low proliferation ability, dedifferentiation...

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Autores principales: Chen, Jie-Lin, Duan, Li, Zhu, Weimin, Xiong, Jianyi, Wang, Daping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233628/
https://www.ncbi.nlm.nih.gov/pubmed/24708713
http://dx.doi.org/10.1186/1479-5876-12-88
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author Chen, Jie-Lin
Duan, Li
Zhu, Weimin
Xiong, Jianyi
Wang, Daping
author_facet Chen, Jie-Lin
Duan, Li
Zhu, Weimin
Xiong, Jianyi
Wang, Daping
author_sort Chen, Jie-Lin
collection PubMed
description Cartilage tissue engineering is arising as a technique for the repair of cartilage lesions in clinical applications. However, fibrocartilage formation weakened the mechanical functions of the articular, which compromises the clinical outcomes. Due to the low proliferation ability, dedifferentiation property and low production of cartilage-specific extracellular matrix (ECM) of the chondrocytes, the cartilage synthesis in vitro has been one of the major limitations for obtaining high-quality engineered cartilage constructs. This review discusses cells, biomaterial scaffolds and stimulating factors that can facilitate the cartilage-specific ECM production and accumulation in the in vitro culture system. Special emphasis has been put on the factors that affect the production of ECM macromolecules such as collagen type II and proteoglycans in the review, aiming at providing new strategies to improve the quality of tissue-engineered cartilage.
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spelling pubmed-42336282014-11-18 Extracellular matrix production in vitro in cartilage tissue engineering Chen, Jie-Lin Duan, Li Zhu, Weimin Xiong, Jianyi Wang, Daping J Transl Med Review Cartilage tissue engineering is arising as a technique for the repair of cartilage lesions in clinical applications. However, fibrocartilage formation weakened the mechanical functions of the articular, which compromises the clinical outcomes. Due to the low proliferation ability, dedifferentiation property and low production of cartilage-specific extracellular matrix (ECM) of the chondrocytes, the cartilage synthesis in vitro has been one of the major limitations for obtaining high-quality engineered cartilage constructs. This review discusses cells, biomaterial scaffolds and stimulating factors that can facilitate the cartilage-specific ECM production and accumulation in the in vitro culture system. Special emphasis has been put on the factors that affect the production of ECM macromolecules such as collagen type II and proteoglycans in the review, aiming at providing new strategies to improve the quality of tissue-engineered cartilage. BioMed Central 2014-04-05 /pmc/articles/PMC4233628/ /pubmed/24708713 http://dx.doi.org/10.1186/1479-5876-12-88 Text en Copyright © 2014 Chen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Chen, Jie-Lin
Duan, Li
Zhu, Weimin
Xiong, Jianyi
Wang, Daping
Extracellular matrix production in vitro in cartilage tissue engineering
title Extracellular matrix production in vitro in cartilage tissue engineering
title_full Extracellular matrix production in vitro in cartilage tissue engineering
title_fullStr Extracellular matrix production in vitro in cartilage tissue engineering
title_full_unstemmed Extracellular matrix production in vitro in cartilage tissue engineering
title_short Extracellular matrix production in vitro in cartilage tissue engineering
title_sort extracellular matrix production in vitro in cartilage tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233628/
https://www.ncbi.nlm.nih.gov/pubmed/24708713
http://dx.doi.org/10.1186/1479-5876-12-88
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