Cargando…
Extracellular matrix production in vitro in cartilage tissue engineering
Cartilage tissue engineering is arising as a technique for the repair of cartilage lesions in clinical applications. However, fibrocartilage formation weakened the mechanical functions of the articular, which compromises the clinical outcomes. Due to the low proliferation ability, dedifferentiation...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233628/ https://www.ncbi.nlm.nih.gov/pubmed/24708713 http://dx.doi.org/10.1186/1479-5876-12-88 |
_version_ | 1782344757061615616 |
---|---|
author | Chen, Jie-Lin Duan, Li Zhu, Weimin Xiong, Jianyi Wang, Daping |
author_facet | Chen, Jie-Lin Duan, Li Zhu, Weimin Xiong, Jianyi Wang, Daping |
author_sort | Chen, Jie-Lin |
collection | PubMed |
description | Cartilage tissue engineering is arising as a technique for the repair of cartilage lesions in clinical applications. However, fibrocartilage formation weakened the mechanical functions of the articular, which compromises the clinical outcomes. Due to the low proliferation ability, dedifferentiation property and low production of cartilage-specific extracellular matrix (ECM) of the chondrocytes, the cartilage synthesis in vitro has been one of the major limitations for obtaining high-quality engineered cartilage constructs. This review discusses cells, biomaterial scaffolds and stimulating factors that can facilitate the cartilage-specific ECM production and accumulation in the in vitro culture system. Special emphasis has been put on the factors that affect the production of ECM macromolecules such as collagen type II and proteoglycans in the review, aiming at providing new strategies to improve the quality of tissue-engineered cartilage. |
format | Online Article Text |
id | pubmed-4233628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42336282014-11-18 Extracellular matrix production in vitro in cartilage tissue engineering Chen, Jie-Lin Duan, Li Zhu, Weimin Xiong, Jianyi Wang, Daping J Transl Med Review Cartilage tissue engineering is arising as a technique for the repair of cartilage lesions in clinical applications. However, fibrocartilage formation weakened the mechanical functions of the articular, which compromises the clinical outcomes. Due to the low proliferation ability, dedifferentiation property and low production of cartilage-specific extracellular matrix (ECM) of the chondrocytes, the cartilage synthesis in vitro has been one of the major limitations for obtaining high-quality engineered cartilage constructs. This review discusses cells, biomaterial scaffolds and stimulating factors that can facilitate the cartilage-specific ECM production and accumulation in the in vitro culture system. Special emphasis has been put on the factors that affect the production of ECM macromolecules such as collagen type II and proteoglycans in the review, aiming at providing new strategies to improve the quality of tissue-engineered cartilage. BioMed Central 2014-04-05 /pmc/articles/PMC4233628/ /pubmed/24708713 http://dx.doi.org/10.1186/1479-5876-12-88 Text en Copyright © 2014 Chen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Chen, Jie-Lin Duan, Li Zhu, Weimin Xiong, Jianyi Wang, Daping Extracellular matrix production in vitro in cartilage tissue engineering |
title | Extracellular matrix production in vitro in cartilage tissue engineering |
title_full | Extracellular matrix production in vitro in cartilage tissue engineering |
title_fullStr | Extracellular matrix production in vitro in cartilage tissue engineering |
title_full_unstemmed | Extracellular matrix production in vitro in cartilage tissue engineering |
title_short | Extracellular matrix production in vitro in cartilage tissue engineering |
title_sort | extracellular matrix production in vitro in cartilage tissue engineering |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233628/ https://www.ncbi.nlm.nih.gov/pubmed/24708713 http://dx.doi.org/10.1186/1479-5876-12-88 |
work_keys_str_mv | AT chenjielin extracellularmatrixproductioninvitroincartilagetissueengineering AT duanli extracellularmatrixproductioninvitroincartilagetissueengineering AT zhuweimin extracellularmatrixproductioninvitroincartilagetissueengineering AT xiongjianyi extracellularmatrixproductioninvitroincartilagetissueengineering AT wangdaping extracellularmatrixproductioninvitroincartilagetissueengineering |