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Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam

During a hospital-based diarrhoeal disease study conducted in Ho Chi Minh City, Vietnam from 2009 to 2010, we identified four symptomatic children infected with G26P[19] rotavirus (RV) – an atypical variant that has not previously been reported in human gastroenteritis. To determine the genetic stru...

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Autores principales: My, Phan Vu Tra, Rabaa, Maia A., Donato, Celeste, Cowley, Daniel, Phat, Voong Vinh, Dung, Tran Thi Ngoc, Anh, Pham Hong, Vinh, Ha, Bryant, Juliet E., Kellam, Paul, Thwaites, Guy, Woolhouse, Mark E. J., Kirkwood, Carl D., Baker, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for General Microbiology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233630/
https://www.ncbi.nlm.nih.gov/pubmed/25121549
http://dx.doi.org/10.1099/vir.0.068403-0
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author My, Phan Vu Tra
Rabaa, Maia A.
Donato, Celeste
Cowley, Daniel
Phat, Voong Vinh
Dung, Tran Thi Ngoc
Anh, Pham Hong
Vinh, Ha
Bryant, Juliet E.
Kellam, Paul
Thwaites, Guy
Woolhouse, Mark E. J.
Kirkwood, Carl D.
Baker, Stephen
author_facet My, Phan Vu Tra
Rabaa, Maia A.
Donato, Celeste
Cowley, Daniel
Phat, Voong Vinh
Dung, Tran Thi Ngoc
Anh, Pham Hong
Vinh, Ha
Bryant, Juliet E.
Kellam, Paul
Thwaites, Guy
Woolhouse, Mark E. J.
Kirkwood, Carl D.
Baker, Stephen
author_sort My, Phan Vu Tra
collection PubMed
description During a hospital-based diarrhoeal disease study conducted in Ho Chi Minh City, Vietnam from 2009 to 2010, we identified four symptomatic children infected with G26P[19] rotavirus (RV) – an atypical variant that has not previously been reported in human gastroenteritis. To determine the genetic structure and investigate the origin of this G26P[19] strain, the whole genome of a representative example was characterized, revealing a novel genome constellation: G26–P[19]–I5–R1–C1–M1–A8–N1–T1–E1–H1. The genome segments were most closely related to porcine (VP7, VP4, VP6 and NSP1) and Wa-like porcine RVs (VP1–3 and NSP2–5). We proposed that this G26P[19] strain was the product of zoonotic transmission coupled with one or more reassortment events occurring in human and/or animal reservoirs. The identification of such strains has potential implications for vaccine efficacy in south-east Asia, and outlines the utility of whole-genome sequencing for studying RV diversity and zoonotic potential during disease surveillance.
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spelling pubmed-42336302015-12-01 Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam My, Phan Vu Tra Rabaa, Maia A. Donato, Celeste Cowley, Daniel Phat, Voong Vinh Dung, Tran Thi Ngoc Anh, Pham Hong Vinh, Ha Bryant, Juliet E. Kellam, Paul Thwaites, Guy Woolhouse, Mark E. J. Kirkwood, Carl D. Baker, Stephen J Gen Virol Animal During a hospital-based diarrhoeal disease study conducted in Ho Chi Minh City, Vietnam from 2009 to 2010, we identified four symptomatic children infected with G26P[19] rotavirus (RV) – an atypical variant that has not previously been reported in human gastroenteritis. To determine the genetic structure and investigate the origin of this G26P[19] strain, the whole genome of a representative example was characterized, revealing a novel genome constellation: G26–P[19]–I5–R1–C1–M1–A8–N1–T1–E1–H1. The genome segments were most closely related to porcine (VP7, VP4, VP6 and NSP1) and Wa-like porcine RVs (VP1–3 and NSP2–5). We proposed that this G26P[19] strain was the product of zoonotic transmission coupled with one or more reassortment events occurring in human and/or animal reservoirs. The identification of such strains has potential implications for vaccine efficacy in south-east Asia, and outlines the utility of whole-genome sequencing for studying RV diversity and zoonotic potential during disease surveillance. Society for General Microbiology 2014-12 /pmc/articles/PMC4233630/ /pubmed/25121549 http://dx.doi.org/10.1099/vir.0.068403-0 Text en © 2014 The Authors http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Animal
My, Phan Vu Tra
Rabaa, Maia A.
Donato, Celeste
Cowley, Daniel
Phat, Voong Vinh
Dung, Tran Thi Ngoc
Anh, Pham Hong
Vinh, Ha
Bryant, Juliet E.
Kellam, Paul
Thwaites, Guy
Woolhouse, Mark E. J.
Kirkwood, Carl D.
Baker, Stephen
Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam
title Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam
title_full Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam
title_fullStr Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam
title_full_unstemmed Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam
title_short Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam
title_sort novel porcine-like human g26p[19] rotavirus identified in hospitalized paediatric diarrhoea patients in ho chi minh city, vietnam
topic Animal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233630/
https://www.ncbi.nlm.nih.gov/pubmed/25121549
http://dx.doi.org/10.1099/vir.0.068403-0
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