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Metabolic acidosis and the progression of chronic kidney disease
Metabolic acidosis is a common complication of chronic kidney disease. Accumulating evidence identifies acidosis not only as a consequence of, but as a contributor to, kidney disease progression. Several mechanistic pathways have been identified in this regard. The dietary acid load, even in the abs...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233646/ https://www.ncbi.nlm.nih.gov/pubmed/24708763 http://dx.doi.org/10.1186/1471-2369-15-55 |
| _version_ | 1782344760648794112 |
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| author | Chen, Wei Abramowitz, Matthew K |
| author_facet | Chen, Wei Abramowitz, Matthew K |
| author_sort | Chen, Wei |
| collection | PubMed |
| description | Metabolic acidosis is a common complication of chronic kidney disease. Accumulating evidence identifies acidosis not only as a consequence of, but as a contributor to, kidney disease progression. Several mechanistic pathways have been identified in this regard. The dietary acid load, even in the absence of overt acidosis, may have deleterious effects. Several small trials now suggest that the treatment of acidosis with oral alkali can slow the progression of kidney disease. |
| format | Online Article Text |
| id | pubmed-4233646 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-42336462014-11-18 Metabolic acidosis and the progression of chronic kidney disease Chen, Wei Abramowitz, Matthew K BMC Nephrol Review Metabolic acidosis is a common complication of chronic kidney disease. Accumulating evidence identifies acidosis not only as a consequence of, but as a contributor to, kidney disease progression. Several mechanistic pathways have been identified in this regard. The dietary acid load, even in the absence of overt acidosis, may have deleterious effects. Several small trials now suggest that the treatment of acidosis with oral alkali can slow the progression of kidney disease. BioMed Central 2014-04-03 /pmc/articles/PMC4233646/ /pubmed/24708763 http://dx.doi.org/10.1186/1471-2369-15-55 Text en Copyright © 2014 Chen and Abramowitz; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| spellingShingle | Review Chen, Wei Abramowitz, Matthew K Metabolic acidosis and the progression of chronic kidney disease |
| title | Metabolic acidosis and the progression of chronic kidney disease |
| title_full | Metabolic acidosis and the progression of chronic kidney disease |
| title_fullStr | Metabolic acidosis and the progression of chronic kidney disease |
| title_full_unstemmed | Metabolic acidosis and the progression of chronic kidney disease |
| title_short | Metabolic acidosis and the progression of chronic kidney disease |
| title_sort | metabolic acidosis and the progression of chronic kidney disease |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233646/ https://www.ncbi.nlm.nih.gov/pubmed/24708763 http://dx.doi.org/10.1186/1471-2369-15-55 |
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