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Electrophysiological evidence for change detection in speech sound patterns by anesthetized rats

Human infants are able to detect changes in grammatical rules in a speech sound stream. Here, we tested whether rats have a comparable ability by using an electrophysiological measure that has been shown to reflect higher order auditory cognition even before it becomes manifested in behavioral level...

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Autores principales: Astikainen, Piia, Mällo, Tanel, Ruusuvirta, Timo, Näätänen, Risto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233929/
https://www.ncbi.nlm.nih.gov/pubmed/25452712
http://dx.doi.org/10.3389/fnins.2014.00374
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author Astikainen, Piia
Mällo, Tanel
Ruusuvirta, Timo
Näätänen, Risto
author_facet Astikainen, Piia
Mällo, Tanel
Ruusuvirta, Timo
Näätänen, Risto
author_sort Astikainen, Piia
collection PubMed
description Human infants are able to detect changes in grammatical rules in a speech sound stream. Here, we tested whether rats have a comparable ability by using an electrophysiological measure that has been shown to reflect higher order auditory cognition even before it becomes manifested in behavioral level. Urethane-anesthetized rats were presented with a stream of sequences consisting of three pseudowords carried out at a fast pace. Frequently presented “standard” sequences had 16 variants which all had the same structure. They were occasionally replaced by acoustically novel “deviant” sequences of two different types: structurally consistent and inconsistent sequences. Two stimulus conditions were presented for separate animal groups. In one stimulus condition, the standard and the pattern-obeying deviant sequences had an AAB structure, while the pattern-violating deviant sequences had an ABB structure. In the other stimulus condition, these assignments were reversed. During the stimulus presentation, local-field potentials were recorded from the dura, above the auditory cortex. Two temporally separate differential brain responses to the deviant sequences reflected the detection of the deviant speech sound sequences. The first response was elicited by both types of deviant sequences and reflected most probably their acoustical novelty. The second response was elicited specifically by the structurally inconsistent deviant sequences (pattern-violating deviant sequences), suggesting that rats were able to detect changes in the pattern of three-syllabic speech sound sequence (i.e., location of the reduplication of an element in the sequence). Since all the deviant sound sequences were constructed of novel items, our findings indicate that, similarly to the human brain, the rat brain has the ability to automatically generalize extracted structural information to new items.
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spelling pubmed-42339292014-12-01 Electrophysiological evidence for change detection in speech sound patterns by anesthetized rats Astikainen, Piia Mällo, Tanel Ruusuvirta, Timo Näätänen, Risto Front Neurosci Psychology Human infants are able to detect changes in grammatical rules in a speech sound stream. Here, we tested whether rats have a comparable ability by using an electrophysiological measure that has been shown to reflect higher order auditory cognition even before it becomes manifested in behavioral level. Urethane-anesthetized rats were presented with a stream of sequences consisting of three pseudowords carried out at a fast pace. Frequently presented “standard” sequences had 16 variants which all had the same structure. They were occasionally replaced by acoustically novel “deviant” sequences of two different types: structurally consistent and inconsistent sequences. Two stimulus conditions were presented for separate animal groups. In one stimulus condition, the standard and the pattern-obeying deviant sequences had an AAB structure, while the pattern-violating deviant sequences had an ABB structure. In the other stimulus condition, these assignments were reversed. During the stimulus presentation, local-field potentials were recorded from the dura, above the auditory cortex. Two temporally separate differential brain responses to the deviant sequences reflected the detection of the deviant speech sound sequences. The first response was elicited by both types of deviant sequences and reflected most probably their acoustical novelty. The second response was elicited specifically by the structurally inconsistent deviant sequences (pattern-violating deviant sequences), suggesting that rats were able to detect changes in the pattern of three-syllabic speech sound sequence (i.e., location of the reduplication of an element in the sequence). Since all the deviant sound sequences were constructed of novel items, our findings indicate that, similarly to the human brain, the rat brain has the ability to automatically generalize extracted structural information to new items. Frontiers Media S.A. 2014-11-17 /pmc/articles/PMC4233929/ /pubmed/25452712 http://dx.doi.org/10.3389/fnins.2014.00374 Text en Copyright © 2014 Astikainen, Mällo, Ruusuvirta and Näätänen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Astikainen, Piia
Mällo, Tanel
Ruusuvirta, Timo
Näätänen, Risto
Electrophysiological evidence for change detection in speech sound patterns by anesthetized rats
title Electrophysiological evidence for change detection in speech sound patterns by anesthetized rats
title_full Electrophysiological evidence for change detection in speech sound patterns by anesthetized rats
title_fullStr Electrophysiological evidence for change detection in speech sound patterns by anesthetized rats
title_full_unstemmed Electrophysiological evidence for change detection in speech sound patterns by anesthetized rats
title_short Electrophysiological evidence for change detection in speech sound patterns by anesthetized rats
title_sort electrophysiological evidence for change detection in speech sound patterns by anesthetized rats
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233929/
https://www.ncbi.nlm.nih.gov/pubmed/25452712
http://dx.doi.org/10.3389/fnins.2014.00374
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