Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions

BACKGROUND: Deregulation of receptor tyrosine kinases (RTK) contributes to the initiation and progression of intestinal-derived epithelial cancers, including colorectal cancer (CRC). However, the roles of the proximal signaling molecules engaged by RTKs in different oncogenic functions of CRC remain...

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Detalles Bibliográficos
Autores principales: Pomerleau, Véronique, Landry, Mélissa, Bernier, Jimmy, Vachon, Pierre H, Saucier, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234027/
https://www.ncbi.nlm.nih.gov/pubmed/24708867
http://dx.doi.org/10.1186/1471-2407-14-240

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