Cargando…

A retrospective study showing maintenance treatment options for paediatric CD in the first year following diagnosis after induction of remission with EEN: supplemental enteral nutrition is better than nothing!

BACKGROUND: A limited body of research suggests that ongoing maintenance enteral nutrition (MEN) can be beneficial in maintaining disease remission in Crohn’s Disease (CD). We aimed to assess how achievable MEN is and whether it helps to prolong remission. METHODS: Patients newly diagnosed with CD i...

Descripción completa

Detalles Bibliográficos
Autores principales: Duncan, Hazel, Buchanan, Elaine, Cardigan, Tracey, Garrick, Vikki, Curtis, Lee, McGrogan, Paraic, Barclay, Andrew, Russell, Richard K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234202/
https://www.ncbi.nlm.nih.gov/pubmed/24645851
http://dx.doi.org/10.1186/1471-230X-14-50
_version_ 1782344809486221312
author Duncan, Hazel
Buchanan, Elaine
Cardigan, Tracey
Garrick, Vikki
Curtis, Lee
McGrogan, Paraic
Barclay, Andrew
Russell, Richard K
author_facet Duncan, Hazel
Buchanan, Elaine
Cardigan, Tracey
Garrick, Vikki
Curtis, Lee
McGrogan, Paraic
Barclay, Andrew
Russell, Richard K
author_sort Duncan, Hazel
collection PubMed
description BACKGROUND: A limited body of research suggests that ongoing maintenance enteral nutrition (MEN) can be beneficial in maintaining disease remission in Crohn’s Disease (CD). We aimed to assess how achievable MEN is and whether it helps to prolong remission. METHODS: Patients newly diagnosed with CD in 2010 and 2011 who commenced exclusive enteral nutrition (EEN) for 8 weeks were followed up for a year post diagnosis. All patients who took EEN were encouraged to continue MEN post EEN. Data on azathioprine use was also collected. Categorical variables were compared using chi–square/Fischer’s exact test. Medians were expressed along with complete data ranges. RESULTS: 59 patients (34 male, median age 11.07 years, range 2.5-16.33 years) were identified. 11/59 (18%) had a poor response to EEN and were switched to steroids. 48/59 patients completed 8 weeks EEN and achieved clinical remission/response. 46/48 patients received Modulen IBD(®), 29/48 (60%) consumed EEN orally and 19/48 (40%) via NGT. 15/48 (31%) patients were able to continue MEN post EEN completion. MEN was consumed for a mean of 10.8 months (range 4–14 months). 14/15 patients drank MEN and 1/15 had MEN via NGT. Remission rates at 1 year in patients continuing MEN were 60% (9/15) compared to15% (2/13) in patients taking no treatment (p = 0.001) and 65% (13/20) in patients taking azathioprine (p = 0.14). CONCLUSION: A sub group of patients can continue MEN as a maintenance treatment and this seems a useful strategy, especially in those who are not commencing azathioprine.
format Online
Article
Text
id pubmed-4234202
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-42342022014-11-18 A retrospective study showing maintenance treatment options for paediatric CD in the first year following diagnosis after induction of remission with EEN: supplemental enteral nutrition is better than nothing! Duncan, Hazel Buchanan, Elaine Cardigan, Tracey Garrick, Vikki Curtis, Lee McGrogan, Paraic Barclay, Andrew Russell, Richard K BMC Gastroenterol Research Article BACKGROUND: A limited body of research suggests that ongoing maintenance enteral nutrition (MEN) can be beneficial in maintaining disease remission in Crohn’s Disease (CD). We aimed to assess how achievable MEN is and whether it helps to prolong remission. METHODS: Patients newly diagnosed with CD in 2010 and 2011 who commenced exclusive enteral nutrition (EEN) for 8 weeks were followed up for a year post diagnosis. All patients who took EEN were encouraged to continue MEN post EEN. Data on azathioprine use was also collected. Categorical variables were compared using chi–square/Fischer’s exact test. Medians were expressed along with complete data ranges. RESULTS: 59 patients (34 male, median age 11.07 years, range 2.5-16.33 years) were identified. 11/59 (18%) had a poor response to EEN and were switched to steroids. 48/59 patients completed 8 weeks EEN and achieved clinical remission/response. 46/48 patients received Modulen IBD(®), 29/48 (60%) consumed EEN orally and 19/48 (40%) via NGT. 15/48 (31%) patients were able to continue MEN post EEN completion. MEN was consumed for a mean of 10.8 months (range 4–14 months). 14/15 patients drank MEN and 1/15 had MEN via NGT. Remission rates at 1 year in patients continuing MEN were 60% (9/15) compared to15% (2/13) in patients taking no treatment (p = 0.001) and 65% (13/20) in patients taking azathioprine (p = 0.14). CONCLUSION: A sub group of patients can continue MEN as a maintenance treatment and this seems a useful strategy, especially in those who are not commencing azathioprine. BioMed Central 2014-03-20 /pmc/articles/PMC4234202/ /pubmed/24645851 http://dx.doi.org/10.1186/1471-230X-14-50 Text en Copyright © 2014 Duncan et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Duncan, Hazel
Buchanan, Elaine
Cardigan, Tracey
Garrick, Vikki
Curtis, Lee
McGrogan, Paraic
Barclay, Andrew
Russell, Richard K
A retrospective study showing maintenance treatment options for paediatric CD in the first year following diagnosis after induction of remission with EEN: supplemental enteral nutrition is better than nothing!
title A retrospective study showing maintenance treatment options for paediatric CD in the first year following diagnosis after induction of remission with EEN: supplemental enteral nutrition is better than nothing!
title_full A retrospective study showing maintenance treatment options for paediatric CD in the first year following diagnosis after induction of remission with EEN: supplemental enteral nutrition is better than nothing!
title_fullStr A retrospective study showing maintenance treatment options for paediatric CD in the first year following diagnosis after induction of remission with EEN: supplemental enteral nutrition is better than nothing!
title_full_unstemmed A retrospective study showing maintenance treatment options for paediatric CD in the first year following diagnosis after induction of remission with EEN: supplemental enteral nutrition is better than nothing!
title_short A retrospective study showing maintenance treatment options for paediatric CD in the first year following diagnosis after induction of remission with EEN: supplemental enteral nutrition is better than nothing!
title_sort retrospective study showing maintenance treatment options for paediatric cd in the first year following diagnosis after induction of remission with een: supplemental enteral nutrition is better than nothing!
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234202/
https://www.ncbi.nlm.nih.gov/pubmed/24645851
http://dx.doi.org/10.1186/1471-230X-14-50
work_keys_str_mv AT duncanhazel aretrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT buchananelaine aretrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT cardigantracey aretrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT garrickvikki aretrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT curtislee aretrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT mcgroganparaic aretrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT barclayandrew aretrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT russellrichardk aretrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT duncanhazel retrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT buchananelaine retrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT cardigantracey retrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT garrickvikki retrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT curtislee retrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT mcgroganparaic retrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT barclayandrew retrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing
AT russellrichardk retrospectivestudyshowingmaintenancetreatmentoptionsforpaediatriccdinthefirstyearfollowingdiagnosisafterinductionofremissionwitheensupplementalenteralnutritionisbetterthannothing